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What is Rybelsus?

Rybelsus is a type 2 diabetes medication that contains semaglutide. It is used to assist in managing blood sugar levels. Although semaglutide is known to help with weight loss, Rybelsus is currently only approved by the FDA to treat type 2 diabetes.

Rybelsus works by increasing the body's insulin production and decreasing the secretion of glucagon. This medication belongs to the class of drugs called GLP-1 receptor agonists. [1] You can learn about Rybelsus in detail by reading our new patient's guide to Rybelsus.

Order Rybelsus from a Canadian online pharmacy like Canada Pharmacy Depot today and save.

Rybelsus Cost

Minimizing the cost of Rybelsus is essential for those managing type 2 diabetes. Canada Pharmacy Depot understands the importance of affordability in maintaining effective treatment, which is why the pricing options above are transparent and competitive, offering a range of doses to suit individual needs. A 30-day supply of Rybelsus at 3 mg is priced at $314, while the 7 mg option comes in at $319. For those requiring a higher dosage, the 14 mg option is available at $354 for a 30-day supply. Whichever dosage you need, a Canadian online pharmacy helps to reduce the cost of Rybelsus so that you can focus on managing your condition. 


  1. [1]  Sally Hughes and Joshua J. Neumiller Oral Semaglutide

Rybelsus is available as a tablet. Take this tablet by mouth at least 30 minutes before your first meal. Avoid taking this medication on a full stomach as your body absorbs it best on an empty stomach.

If you need help swallowing the Rybelsus tablet whole, take it with water. If you need to take Rybelsus alongside other diabetes medication, wait at least 30 minutes after taking Rybelsus to take another oral drug.

To manage type 2 diabetes safely and effectively with Rybelsus, follow these directions carefully:

  • Take Rybelsus once daily, at least 30 minutes before your first meal of the day.
  • Swallow the Rybelsus tablet whole with a glass of water. Avoid chewing, crushing, or splitting the tablet.
  • Do not adjust the dosage without consulting your doctor. 
  • Regularly monitor your blood sugar levels to ensure Rybelsus is working for you.
  • Contact your healthcare provider if you experience severe adverse effects.


Rybelsus may not be right for you if you have a history of pancreatitis, eye problems, or kidney failure. Additionally, you should not take Rybelsus if you have a known allergy to semaglutide, the active ingredient in this medication. 

Avoid taking Rybelsus with other medication that lowers blood sugar. Doing so may result in excessively low blood sugar. Although Rybelsus does not interact with alcohol, you should consult your healthcare provider about whether it's safe to consume alcohol during the duration of your treatment. 

It is not known if semaglutide passes into breast milk. For pregnant or breastfeeding patients, ask your doctor about properly managing diabetes so that the baby is not harmed during treatment. Understanding the important precautions to take for Rybelsus will ensure fewer adverse effects and a more beneficial treatment journey.

Side Effects

This type 2 diabetes drug may cause mild side effects like nausea, vomiting, constipation, weight loss, and stomach pain. Diarrhea and a loss of appetite may also occur. However, not everyone taking Rybelsus experiences these side effects. More severe side effects of Rybelsus include:

  • Vision disturbances
  • Low blood sugar
  • Thyroid cancer
  • Pancreatitis (inflammation in the pancreas)
  • Kidney problems

These severe side effects are rare. Still, we advise you to see your doctor if you experience any of the above-listed side effects (especially if they persist for a long time). To reduce the risk of these side effects, make sure you tell your doctor about all the medications you are taking before starting treatment. 


Can I use Rybelsus for weight loss?

Rybelsus is primarily used to treat type 2 diabetes, but it has been associated with weight loss. In one case, a 61-year-old woman with obesity lost about 17 lbs after taking Rybelsus 7 mg once daily for four months. [2] 

While Rybelsus is not indicated specifically for weight loss, some healthcare providers may recommend it as an off-label weight management solution. If you are using Rybelsus as an off-label medication to lose weight, it is important to use it under the guidance of your doctor, who can assess your individual health factors and treatment needs.

How does Rybelsus work?

Rybelsus contains the active ingredient semaglutide, which helps patients manage blood sugar levels by increasing the amount of insulin the body releases when blood sugar levels are elevated. With more insulin, the body is able to store glucose as energy instead of letting it build up in your bloodstream.

Why is Rybelsus so expensive?

Rybelsus is considered one of the most effective medications in the treatment of type 2 diabetes. As such, it may come with a higher price tag than several other medications.

The good news is you can save on your treatment by ordering Rybelsus from an online Canadian pharmacy like Canada Pharmacy Depot. We ship brand-name Rybelsus directly to your door at a fraction of the price.

How long does Rybelsus stay in your system?

In a 10-week trial, researchers found that Rybelsus has a half-life of seven days. While the actual half-life of the drug will vary between patients, Rybelsus is estimated to completely leave the body after approximately 35 days.

How long does it take for Rybelsus to start working?

Some patients may experience improved glycemic control within just a few days, while others may need a few weeks or more to adjust to the medication. It is common for doctors to prescribe a lower dose of 3 mg for the first month of treatment, followed by an increase to 7 mg afterward. In these cases, Rybelsus becomes more effective after the initial adjustment period and provides more benefits after the first month.

When you increase your dose, it may take 4 to 5 weeks for Rybelsus to reach a steady level in your system. Once this medication has reached a steady level, you will experience the full benefits of Rybelsus. It is important to continue monitoring your blood sugar levels when taking Rybelsus and report any side effects to your doctor. 

How long do Rybelsus side effects last?

Common side effects of Rybelsus, including nausea and diarrhea, typically improve as your body adjusts to the medication. How quickly your side effects resolve themselves will depend on factors like your metabolism and dosage.

While some side effects go away in a day or two, others may take up to a few weeks to go away. You can take steps to avoid Rybelsus side effects, such as staying hydrated and eating a fiber-rich diet. If any of your side effects worsen, talk to your doctor to ensure the safe use of Rybelsus.

How long after eating can I take Rybelsus?

Taking Rybelsus at least 30 minutes before the first meal of the day allows your body to properly absorb the medication. Taking Rybelsus on an empty stomach is necessary for proper absorption, so you should always take your dose in the morning before eating.

In addition to taking Rybelsus on an empty stomach, it is important to avoid chewing or crushing the tablet. If you have to take Rybelsus after eating, you should wait long enough so that you are still taking it on an empty stomach. Work with your doctor to optimize your dosing schedule.


  1. [2]  Ogawa H., Bando H., Abe T., Nagahiro S., Nakanishi M., and Watanabe O. Efficacy For Reduction Of HbA1c And Body Weight By Oral Semaglutide
Dr.Marc Applestein

Medical Content on this page has been reviewed and confirmed for accuracy by

Dr Marc Applestein


Dr. Marc Applestein, M.D. M.S.B. has over 35 years of medical experience, specializing in urology. His expertise in medicine and patient care allows him to bring up-to-date medical information to patients in need.

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JudithNovember 30, 2022

Great job! Very reasonable prices and fast service

KathleenOctober 5, 2022

Good experience.

ElizabethSeptember 30, 2022

Great service and very timely.

ChrisSeptember 30, 2022

Great service from start to finish.

EdwardSeptember 29, 2022

I had wonderful service as I have every time I’ve dealt with you. My questions were answered promptly and I received my medication right on time. Thank you so much.

LindaSeptember 29, 2022

A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

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