Canada Pharmacy Depot Prescription Required
IMPORTANT NOTE: A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.
Available 7 Days a Week


Express shipping

May be available upon request

Lowest Price, Guaranteed

match price or beat it by 10% *

Life-Time Free shipping

Find out if you're eligible!

  • Delivery time is between 8-14 business days.
  • Express shipping may be available upon request

What is Rybelsus?

Rybelsus is a type 2 diabetes medication that contains semaglutide. It is used to assist in managing blood sugar levels. Although semaglutide is known to help with weight loss, Rybelsus is currently only approved by the FDA to treat type 2 diabetes.

Rybelsus works by increasing the body's insulin production and decreasing the secretion of glucagon. This medication belongs to the class of drugs called GLP-1 receptor agonists. [1] Order Rybelsus from a Canadian online pharmacy like Canada Pharmacy Depot today and save.


  1. [1]  Sally Hughes and Joshua J. Neumiller Oral Semaglutide

Rybelsus is available as a tablet. Take this tablet by mouth at least 30 minutes before your first meal. Avoid taking this medication on a full stomach as your body absorbs it best on an empty stomach.

If you need help swallowing the Rybelsus tablet whole, take it with water. If you need to take Rybelsus alongside other diabetes medication, wait at least 30 minutes after taking Rybelsus to take another oral drug.


Rybelsus may not be right for you if you have a history of pancreatitis, eye problems, or kidney failure. Additionally, you should not take Rybelsus if you have a known allergy to semaglutide, the active ingredient in this medication. 

Avoid taking Rybelsus with other medication that lowers blood sugar. Doing so may result in excessively low blood sugar. Although Rybelsus does not interact with alcohol, you should consult your healthcare provider about whether it's safe to drink during the duration of your treatment. 

It is not known if semaglutide passes into breast milk. For pregnant or breastfeeding patients, ask your doctor about properly managing diabetes so that the baby is not harmed during treatment.

Side Effects

This type 2 diabetes drug may cause mild side effects like nausea, vomiting, constipation, weight loss, and stomach pain. Diarrhea and a loss of appetite may also occur. However, not everyone taking Rybelsus experiences these side effects. More severe side effects of Rybelsus include:

  • Vision disturbances
  • Low blood sugar
  • Thyroid cancer
  • Pancreatitis (inflammation in the pancreas)
  • Kidney problems

These severe side effects are rare. Still, we advise you to see your doctor if you experience any of the above-listed side effects (especially if they persist for a long time). To reduce the risk of these side effects, make sure you tell your doctor about all the medications you are taking before starting treatment. 


Can I use Rybelsus for weight loss?

No. Even though Rybelsus uses the same ingredients as certain weight loss medications, it is only approved for treating type 2 diabetes.

How does Rybelsus work?

Rybelsus contains the active ingredient semaglutide, which helps patients manage blood sugar levels by increasing the amount of insulin the body releases. With more insulin, the body is able to store glucose as energy instead of letting it build up in your bloodstream.

Why is Rybelsus so expensive?

Rybelsus is considered one of the most effective medications in the treatment of type 2 diabetes. As such, it may come with a higher price tag than several other medications.

The good news is you can save on your treatment by ordering Rybelsus from an online Canadian pharmacy like Canada Pharmacy Depot. We ship brand-name Rybelsus directly to your door at a fraction of the price.

How long does Rybelsus stay in your system?

In a 10-week trial, researchers found that Rybelsus has a half-life of seven days. While the actual half-life of the drug will vary between patients, Rybelsus is estimated to completely leave the body after approximately 35 days.

Real Customers, Trustworthy Reviews

Read what others have to say before you buy — honest reviews from real people.


JudithNovember 30, 2022

Great job! Very reasonable prices and fast service

KathleenOctober 5, 2022

Good experience.

ElizabethSeptember 30, 2022

Great service and very timely.

ChrisSeptember 30, 2022

Great service from start to finish.

EdwardSeptember 29, 2022

I had wonderful service as I have every time I’ve dealt with you. My questions were answered promptly and I received my medication right on time. Thank you so much.

LindaSeptember 29, 2022

A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

Your Lowest Price, Guaranteed

Our goal is to bring you the most affordable medication. If you find a lower price advertised by another website or your local pharmacy, we’ll match that price or beat it by 10% of the difference.* Call us at 1-877-204-1507 and a member of our CareTeam will be happy to assist you.

Call 1-877-204-1507
* Some exceptions may apply
Some exceptions may apply. To qualify for price matching, competitors must meet our standards for patient safety. Advertised prices must be for medication of the same type, strength, quantity, and form.