Canada Pharmacy Depot

Is Rybelsus the Best Drug for Type 2 Diabetes?

Tuesday 26 September 2023
5 minute(s) read

Table of Contents

I. How To Use Rybelsus for Diabetes

II. Can I Use Rybelsus for Weight Loss?

III. Rybelsus vs Ozempic

IV. Rybelsus vs Jardiance

V. Rybelsus vs Metformin

VI. What Is the Best Drug for Type 2 Diabetes?

When it comes to managing type 2 diabetes, there's no one-size-fits-all approach. The choice of medication depends on various factors, including individual health conditions and preferences.

In this article, we'll discuss the role of Rybelsus in weight loss and type 2 diabetes. We’ll also compare Rybelsus to other diabetes drugs such as Ozempic, Jardiance, and Metformin.

How To Use Rybelsus for Diabetes

Rybelsus (semaglutide) falls under the category of GLP-1 receptor agonists. It stands out because it's available in a pill form, a departure from the usual injections associated with other semaglutide medications. [1] This offers a solution for individuals who are unable to self-inject.

Rybelsus was FDA-approved in 2017 to treat type 2 diabetes by

  • Stimulating the pancreas to release more insulin when blood sugar is high.
  • Slowing down stomach emptying so you feel full for a longer time.
  • Preventing the liver from creating and releasing too much sugar. [2]

Typically, Rybelsus is taken once daily on an empty stomach 30 minutes before consuming food or other medications. Properly adhering to these instructions ensures optimal absorption of the medication. [1]

If you have recently been prescribed Rybelsus, your physician will typically start you on 3 mg once daily for 30 days. This low dosage allows your body to adjust to the medication. Afterward, the dosage will increase to 7 mg once daily for another 30 days. If you need additional glycemic control after 30 days, your doctor will increase your dosage to 14 mg once daily. [3]

Please note that while this is the recommended dosage schedule, your doctor may prescribe a modified regimen suited to your unique health profile. Strict adherence to your healthcare provider's guidance is paramount when incorporating Rybelsus into your diabetes management plan.

a person standing on a scale

Can I Use Rybelsus for Weight Loss?

Weight management is often a key concern when managing type 2 diabetes, and Rybelsus offers an intriguing solution. A 26-week-long study referenced by the FDA found that Rybelsus 7 mg and 14 mg resulted in weight loss of 2.3 kg and 3.7 kg, respectively. [1]

However, it's important to acknowledge that Rybelsus is not FDA-approved for weight loss.  While the medication may help you lose weight, the intended purpose of Rybelsus is to help manage type 2 diabetes. [4]

To experience optimal results on Rybelsus (which may include weight loss), it's essential to incorporate healthy lifestyle modifications in addition to taking the medication. These modifications can consist of a more nutritious diet and daily exercise. [1]

Rybelsus vs Ozempic

Ozempic, another GLP-1 receptor agonist, is often in the diabetes medication spotlight alongside Rybelsus. These two drugs share a similar mechanism of action but differ in administration. While Rybelsus is taken orally once daily, Ozempic requires a once-weekly subcutaneous injection. The choice between the two often boils down to individual preference and physician recommendation. [5]

Like Rybelsus, Ozempic is prescribed in a gradually increasing dosage so your body can adjust to the medication. Your physician will typically start you on a dosage of 0.25 mg once weekly for the first four weeks. Afterward, the dosage will increase to 0.5 mg once weekly for another four weeks. If additional blood sugar control is needed, your dosage will increase to 1 mg once weekly for four weeks. If more blood sugar control is required, your dosage will increase to a maximum of 2 mg once weekly. [6]

a lady taking a pill

Rybelsus vs Jardiance

Like Rybelsus, Jardiance is an oral medication prescribed for type 2 diabetes. However, it belongs to a different class of medications called SGLT2 inhibitors. Its mode of action involves reducing glucose reabsorption by the kidneys and facilitating its excretion through urine. [7]

In addition to treating type 2 diabetes, Jardiance is also FDA-approved to reduce the risk of cardiovascular death and hospitalization in individuals with type 2 diabetes or cardiovascular disease. The choice between Rybelsus and Jardiance depends on factors such as co-existing health conditions and physician recommendation. [7]

Jardiance is available as a 10 mg or 25 mg tablet. Your physician will work with you to determine the best dosage for your treatment plan. Jardiance is typically taken once daily with or without food. [7]

Rybelsus vs Metformin

Metformin is commonly prescribed to patients newly diagnosed with type 2 diabetes. Metformin is preferred as an initial therapy because of its effectiveness in controlling blood sugar levels, low cost, and tolerability by most patients. [8]

Metformin’s mode of action differs from Rybelsus. Metformin curbs the liver's glucose production and enhances insulin sensitivity in muscle cells. [9] Rybelsus can be added onto Metformin when additional blood sugar control is needed. [1]

a doctor giving a

What Is the Best Drug for Type 2 Diabetes?

Choosing the proper medication for type 2 diabetes is a decision that should be made with your healthcare provider. The selection process considers an array of factors, including overall health, the severity of diabetes, preferences for medication administration, and co-existing health conditions.

While Rybelsus offers an enticing option due to its potential for blood sugar control, weight management, and oral administration, the final decision must be made based on your health and medical history. Diabetes management is unique to every patient, and the right medication choice can profoundly impact your overall health and well-being.

At Canada Pharmacy Depot, we understand the vast medication options for type 2 diabetes can become overwhelming. If you have questions about any medications, please contact our friendly team of pharmacists.

The content provided in this article is based on thorough research and in some cases, reviewed by a medical professional. Our goal for the information is to provide helpful, general health informational. It is not intended as a substitute for professional medical advice.