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What is Medrol?

Medrol (methylprednisolone) is a prescription corticosteroid used to treat several health conditions, including arthritis, lupus, psoriasis, ulcerative colitis, allergic disorders, and endocrine disorders. Medrol may also be prescribed for treating conditions that affect the blood cells, eyes, lungs, nervous system, skin, or stomach.

How does Medrol work?

Medrol works by slowing down an overactive immune system and decreasing inflammation in the body. Medrol also helps replace cortisol, which is a hormone responsible for regulating stress and managing illness. By reducing your immune system's response to certain diseases, Medrol can help reduce symptoms like swelling, pain, and allergic reactions.

Medrol is an oral medication that you may take with food. Since Medrol is used to treat a wide range of health conditions, refer to your doctor's instructions for your dosing schedule. 

For treatment plans that include daily dosing, take your dose at the same time each day to help you remember. Do not take more than prescribed, or severe side effects may occur. When stopping Medrol, it is important to lower your dose gradually to minimize the risk of withdrawal symptoms.

Precautions

Tell your doctor before you start taking Medrol if you have a history of osteoporosis, diabetes, or high blood pressure. Other health conditions that may affect how Medrol works include kidney disease, heart problems, and past blood clots. 

Medrol may interact with many diseases, so it is important to inform your doctor of your complete medical history to determine if Medrol is right for you. 

Long-term use of corticosteroid medications such as Medrol makes it more difficult for your body to handle physical stress. Ensure you tell your doctor or dentist before any procedures that you are taking Medrol.

Side Effects

The more common side effects of Medrol may include:

  • headache
  • nausea and vomiting
  • weight gain
  • confusion, excitement, and restlessness
  • swelling of your ankles, feet, or hands
  • skin problems, such as acne, thin skin, and shiny skin
  • increased thirst
  • infection
  • high blood pressure
  • muscle weakness
  • depression


These effects may go away within a few days or a couple of weeks if they are mild. Talk to your doctor or pharmacist if they’re more severe or don’t go away.

FAQs

What is Medrol?

Medrol is a prescription corticosteroid medication used to reduce inflammation and slow the body's immune response to certain conditions in order to ease symptoms. It can be prescribed for a wide range of health problems, including eye conditions, arthritis, allergic reactions, and immune system disorders.

Does Medrol cause weight gain?

Medrol can cause weight gain. However, it's more likely to happen with higher doses and if you use the medication for a long time. By maintaining healthy lifestyle habits—such as eating less refined sugar, getting enough sleep, and exercising—it is possible to minimize the weight gain caused by Medrol.

What are Medrol side effects?

Medrol can cause side effects like nausea, vomiting, heartburn, and headache. Other reported side effects include dizziness, trouble sleeping, appetite changes, increased sweating, and acne. Report your side effects to your doctor to make the necessary treatment adjustments.

What drugs interact with Medrol?

Before taking Medrol, it is important to tell your doctor about all the medications you are currently taking. Medrol may interact with a wide range of drugs, including NSAIDs, blood thinners, and certain antiplatelet medications. Consult your physician for a complete list of Medrol drug interactions.

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We have had very good service from the Canada Pharmacy Depot, obtaining a very expensive medication (in the USA) for the very same medication from India for a fraction of the US cost ($488/3mo supply vs $1400/1mo supply). This has been a godsend bc my husband has Parkinson's Disease and takes many medications to manage his condition. It does take longer to get the medication, but you just have to plan ahead for significant savings.

JoyceJanuary 29, 2026

So nice and easy to order and arrange payment by phone...especially for this OLD person who is "computer resistive(illiterate)"

PeterJanuary 25, 2026

I called with the purpose of refilling my order. The person I interacted with was polite, careful, and efficient. Very well organized and fastidious about verifying the details of my order and payment.

CharlesJanuary 22, 2026

The Canadian Depot Pharmacy always updates me on my orders. Easy to use and a big cost savings.

DebbieJanuary 20, 2026

Outstanding customer service and courtesy. Thank you for helping to resolve my issue with my order for Eliquis.

DonnaJanuary 16, 2026

Always excellent and a pleasure!

JosephJanuary 15, 2026

A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

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