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What is Linzess and How Does it Work?

Linzess is an oral medication that directly targets the gut to relieve constipation in adults and children over six years old. It was first approved by the FDA in 2012 for:

  • Irritable bowel syndrome with constipation (IBS-C) in adults
  • Chronic idiopathic constipation (CIC) in adults
  • Functional constipation (FC) in children above six years of age

The active ingredient in Linzess is linaclotide, which activates receptors called guanylate cyclase-C (GC-C) in the intestinal lining. This kickstarts a series of effects that soften stool and promote bowel movements.

Specifically, turning on GC-C causes intestinal cells to release ions like chloride and bicarbonate. These ions draw water into the intestines, hydrating and lubricating stool. Linaclotide also calms nerves in the gut that sense pain, reducing discomfort.

With an online Canadian pharmacy like Canada Pharmacy Depot, you can save up to 90% on Linzess. Talk to your doctor to see if Linzess is right for you.

Linzess comes in three capsule strengths to treat various gastrointestinal conditions. The Linzess dosage prescribed to you will depend on your specific diagnosis:

  • 72 mcg capsules are typically prescribed for children ages six and up who have functional constipation. This low dose may also be an option for adults who have chronic idiopathic constipation but experience side effects from the 145-mcg dose.
  • 145 mcg capsules are the standard dose for chronic idiopathic constipation in adults.
  • 290 mcg capsules are the highest dose for Linzess. This maximum-strength option is approved for adults with irritable bowel syndrome with constipation (IBS-C). 

Common Side Effects of Linzess

Linzess works directly in the gastrointestinal tract, so most side effects are related to the stomach and intestines. However, these side effects are usually mild and tend to subside within a couple of weeks of starting treatment.

  • Diarrhea is the most common side effect of Linzess. Linzess causes more fluid to enter the intestines, leading to watery stools. For most people, this diarrhea is mild. But in rare cases, it can be severe. 
  • Gas: Increased fluid in the intestines can also cause gas and bloating. It's common to pass more gas while taking Linzess. Although it can be uncomfortable, this side effect is temporary.
  • Stomach Pain: Linzess stimulates contractions in the intestines, which sometimes causes cramping or stomach pain.

Who Shouldn’t Take Linzess?

Linzess may not be right for everyone. Your doctor will consider your full medical history before prescribing this medication. Some people who should avoid Linzess include:

  • Individuals with intestinal blockage: Linzess is designed to stimulate bowel movements and increase the speed at which stool moves through the intestines. For someone with an existing blockage, this effect could potentially make the blockage worse and lead to dangerous complications. 
  • Individuals under the age of six: The FDA has issued a serious warning against using Linzess in children under two due to the risk of life-threatening dehydration. Although the warning specifically focuses on infants and toddlers, Linzess is not approved for any child under six while the effects on young children are still being studied.


What is Linzess used for?

Linzess is an oral medication that relieves specific types of constipation by improving bowel movements. It’s FDA-approved to treat IBS-C, chronic idiopathic constipation, and functional constipation.

How long does Linzess take to work?

Many individuals have reported experiencing relief from constipation within the first week of using Linzess. As you continue taking the medication over the next four to twelve weeks, you may observe several positive changes:

  • Fewer episodes of constipation overall
  • Stools that are softer and easier to pass
  • Less painful straining when you do have a bowel movement
  • Decreased bloating and abdominal discomfort

How do I take Linzess?

Linzess is an oral capsule taken once daily. It is important to take your prescribed dosage of Linzess daily for the best results, even if you are not feeling constipated. Unlike laxatives, which can be taken only when needed, Linzess works best when taken daily.

To maximize the benefits of your Linzess treatment, take your daily dose on an empty stomach at least 30 minutes before eating breakfast. Taking the medication without food allows your body to fully absorb it without any interference from what you have eaten. If swallowing the entire capsule is uncomfortable, the contents can be mixed into either water or applesauce. The medication will still work the same when taken this way.

What should I do if I miss a dose of Linzess?

If you miss a dose of Linzess, skip it and continue with your regular dosing schedule. Do not double up or take extra doses to make up for the missed one.

Linzess works best when taken consistently at the same time each day. Missing one dose will not disrupt its effects, but skipping multiple doses may cause your constipation and symptoms to return.

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JudithNovember 30, 2022

Great job! Very reasonable prices and fast service

KathleenOctober 5, 2022

Good experience.

ElizabethSeptember 30, 2022

Great service and very timely.

ChrisSeptember 30, 2022

Great service from start to finish.

EdwardSeptember 29, 2022

I had wonderful service as I have every time I’ve dealt with you. My questions were answered promptly and I received my medication right on time. Thank you so much.

LindaSeptember 29, 2022

A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

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