Canada Pharmacy Depot

How to Take Linzess Properly

Tuesday 2 April 2024
6 minute(s) read

Table of Contents

I. Linzess Dosages

II. How to Take Linzess

III. Missing a Linzess Dose

IV. Conclusion

Chronic constipation can be a challenging condition to manage, but for those seeking relief, Linzess may offer a promising solution.

To get the maximum benefit from Linzess, it is important to understand how to take this medication properly. The dosage and administration method can significantly impact how well it works for you.

In this article, we'll explore Linzess dosages, how to take it, what to do if you miss a dose, and tips to help you remember to take your daily dose.

Linzess Dosages

When you start taking Linzess, finding the optimal dosage is important for managing your symptoms effectively. Linzess capsules come in three strengths:

  • 72 mcg
  • 145 mcg
  • 290 mcg [1]

Your doctor will work with you to decide which dosage suits your needs. Some key factors influence which dosage your doctor recommends:

  • Your diagnosis: Your dosage depends on the condition Linzess is treating.
  • Symptom severity: More intense symptoms often need higher doses for adequate relief. Milder cases can typically start with a lower dose.
  • Your response: Your doctor may have you try a lower dose first, then increase it over time. This helps find the lowest effective dose with fewer side effects. [1]

Dosage needs can change over time. Your doctor will monitor your symptoms and adjust the Linzess dosage as needed. 

Linzess Dosage for Irritable Bowel Syndrome with Constipation (IBS-C)

IBS-C is a specific type of irritable bowel syndrome characterized mainly by constipation. [2] Along with constipation, people with IBS-C often experience:

  • Stomach cramps and pain
  • Bloating
  • Increased gas
  • Mucus in stool [2]

It's important to understand that IBS-C is not the same as chronic constipation. While chronic constipation refers only to problems having bowel movements, IBS-C also involves abdominal discomfort and pain. Linzess can relieve symptoms of IBS-C, helping make bowel movements more frequent and comfortable. {{2}]

The recommended dosage of Linzess for IBS-C is 290 mg once daily. [1]

Linzess Dosage for Chronic Idiopathic Constipation (CIC)

CIC is a condition characterized by ongoing constipation without a known cause. With CIC, people have difficulty passing stools and may only have bowel movements a couple of times per week. [3] Common CIC symptoms include:

  • Straining during bowel movements
  • Passing hard or lumpy stools
  • Feeling incomplete emptying after a bowel movement
  • Less frequent bowel movements (fewer than three times per week) [3]

Starting Linzess helps increase the fluid secretion into the intestines to soften stool and improve bowel movement frequency. Common Linzess dosages for CIC are:

  • 145 mcg once daily
  • 72 mcg once daily if the 145 mcg causes increased side effects [1]

Linzess Dosage for Functional Constipation (FC) in Children Above Six Years of Age

Functional constipation is not caused by an underlying medical condition. Rather, it occurs due to a combination of factors, such as:

  • Diet
  • Stress
  • Environment
  • Coping skills
  • Level of support [4]

If your child is struggling with functional constipation, they may show signs like:

  • Passing hard and painful stools
  • Unable to completely empty their bowels
  • Difficult and infrequent bowel movements [4]

To help relieve your child's functional constipation in a gentle way, the recommended Linzess dosage is a lower dosage of 72 mcg taken once daily. [1]

How to Take Linzess

a capsule spilling out medication

Linzess is an oral capsule, meaning you swallow it whole. Take your prescribed dose every day for best results, even if you don't feel constipated. Unlike laxatives, which can be used as needed, Linzess works through consistent, daily use. [5]

To get the most out of your Linzess treatment, take your dose on an empty stomach at least 30 minutes before eating breakfast. This allows your body to absorb the medication without interference from food. If swallowing the whole capsule is uncomfortable, you have a couple of options to make taking Linzess easier. [1]

Taking Linzess in Applesauce

Mixing your Linzess dose into applesauce can help if you have trouble swallowing pills. The soft texture makes it easier to ingest the medication.

  • Put 1 teaspoon of soft applesauce into a small bowl.
  • Carefully open the Linzess capsule over the applesauce and sprinkle the beads onto the applesauce.
  • Use a spoon to gently mix the beads into the applesauce until they are evenly distributed throughout.
  • Swallow the entire applesauce mixture right away. Do not chew the beads. Consuming the full dose immediately provides the most benefit.
  • Never save any of the mixture for later. Always take the full prescribed dose at one time. [1]

Taking Linzess in Water

You can also open your Linzess capsule into water instead of swallowing it whole if that's easier for you. Here's how:

  • Pour about 1 ounce of room-temperature bottled water into a cup.
  • Open the Linzess capsule over the water and sprinkle the beads from the capsule into the water.
  • Gently swirl the cup for at least 20 seconds so the beads mix thoroughly in the water.
  • Drink the entire mixture right away.
  • If any beads remain in the cup, add another ounce of water and, swirl and drink again immediately. [1]

Missing a Linzess Dose

medication bottles in front of an alarm clock

It's best to take Linzess regularly and as your doctor prescribes. However, if you miss a dose, skip it and continue with your regular dosing schedule. Do not double up or take extra doses to make up for the missed one. [1]

Linzess works most effectively when taken consistently every day. If you stop taking Linzess, your constipation and its symptoms are likely to return within a week. [5]

Linzess is not meant to be used as needed, like some over-the-counter laxatives. To get the maximum benefit from Linzess and prevent your constipation from coming back, take it daily as your doctor has directed. [5]

Tips to Remember Your Dose

Taking your daily dose of Linzess is essential to managing your symptoms of irritable bowel syndrome with constipation (IBS-C), chronic idiopathic constipation (CIC), or functional constipation (FC). [1] It’s easy to forget a dose here and there, but if you stop taking Linzess completely, your symptoms can return within a week.

To avoid missing doses, here are some helpful tips:

  • Set a time: Pick a specific time of day that works for your schedule and make your Linzess dose part of your regular routine. Taking it at the same time each day will help your body adjust and get into a regular rhythm.
  • Pair it with your toothbrush: Connect your Linzess dose to another daily habit, like brushing your teeth or making your morning coffee. The association will help jolt your memory.
  • Pack extras when traveling: Avoid running out by packing extra Linzess doses any time you travel. Carry it in your carry-on in case of lost luggage.
  • Mark your calendar: Use a calendar or app to check off each dose you take. Having a visual record helps provide peace of mind that your routine is on track. [6]


To get the most out of your Linzess treatment, it's important to take it properly and consistently. By following the recommended dosages and administration methods, you can optimize the benefits of this medication while minimizing potential complications. 

Stay in touch with your healthcare provider throughout your treatment. They can help adjust your dosage or offer other recommendations if you experience side effects.

To learn more about Linzess, visit our dedicated Linzess blog.

The content provided in this article is based on thorough research and, in some cases, reviewed by a medical professional. Our goal for the information is to provide helpful, general health information. It is not intended as a substitute for professional medical advice.