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What is Wellbutrin SR?

Wellbutrin SR may be prescribed for depression and seasonal affective disorder. It may also be used to reduce withdrawal symptoms in those quitting smoking.

Wellbutrin contains bupropion hydrochloride, an effective antidepressant that works by increasing dopamine and norepinephrine in the brain. The "SR" in the name indicates that this is the sustain-release version of Wellbutrin.

With an online Canadian pharmacy like Canada Pharmacy Depot, you have access to affordable Wellbutrin SR. Talk to your doctor about whether Wellbutrin SR is right for you, and save up to 90% on this medication when you order online from Canada.

Your doctor will prescribe the dosage strength that is best suited for your treatment. Below are the general recommended doses for each condition. 


The recommended starting dose for depression is 150 mg of Wellbutrin SR daily. You will want to take this as a single dose, preferably in the morning. Based on your response to treatment, your doctor may increase your dosage to 450 mg per day. 

Seasonal affective disorder (SAD)

The starting dose for SAD is 150 mg per day. If necessary, your doctor may increase your dosage strength to 300 mg daily. If you require 300 mg daily, your doctor may have you take two 150 mg pills per day so that the dose is divided. 

Smoking Withdrawal Symptoms

A once-daily dose of 150 mg is the usual starting point for those quitting smoking. As with the previous two conditions, it is recommended that you take your daily dose in the morning. The maximum dosage for smoking cessation is 300 mg per day or as instructed by your doctor.

Your Wellbutrin SR dose may be adjusted over time by your healthcare provider. Never take more than you have been prescribed, or serious side effects may occur. If you are experiencing bothersome side effects, speak to your doctor about changing your dose as needed.

Common Side Effects of Wellbutrin

Wellbutrin SR can cause some side effects, but not everyone experiences them. The most common side effects of Wellbutrin SR include:

Dry mouth: This can lead to a feeling of discomfort and can be relieved by drinking water.

Headache: This can be a mild to moderate headache that often improves over time.

Nausea: This is a common side effect that may improve after the first few days of taking the medication.

Insomnia: Some people may experience trouble sleeping while taking Wellbutrin SR.

Agitation or nervousness: Some people may feel jittery or anxious while taking Wellbutrin SR.

Skin rash: A rash or hives may occur in some people who take Wellbutrin SR.

Increased heart rate: This is a rare side effect that may occur in some people who take Wellbutrin SR. [1]

It is important to tell your healthcare provider if you experience any side effects while taking Wellbutrin SR, as they may be able to recommend a different treatment or adjust the dose of the medication. If you experience any serious side effects, such as an allergic reaction, seizures, or changes in behavior, seek immediate medical attention.


  1. [1]  Maurizio Fava, M.D., et al. 5 Years of Clinical Experience With Bupropion

Wellbutrin Drug Interactions

Wellbutrin SR (bupropion hydrochloride sustained-release) can interact with other medications you may be taking, leading to potentially serious or even life-threatening side effects. Some of the most important drug interactions to be aware of with Wellbutrin SR include:

Monoamine oxidase inhibitors (MAOIs): Taking Wellbutrin SR with an MAOI can cause a dangerous increase in blood pressure. You should not take Wellbutrin SR if you are currently taking an MAOI, or if you have taken an MAOI within the past 14 days.

Other antidepressants: Taking Wellbutrin SR with other antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) or tricyclic antidepressants (TCAs), can increase the risk of side effects, such as seizures. Your healthcare provider may need to adjust the dose of Wellbutrin SR if you are taking other antidepressants.

Nicotine replacement therapy: Taking Wellbutrin SR with nicotine replacement therapy (NRT) products, such as nicotine patches or gum, can increase the risk of seizures. Your healthcare provider may need to adjust the dose of Wellbutrin SR or NRT if you are using both.

Alcohol: Drinking alcohol while taking Wellbutrin SR can increase the risk of certain side effects, such as dizziness, drowsiness, and impaired judgment.


What is Wellbutrin SR used for?

Wellbutrin SR is an antidepressant medication that is used to treat major depressive disorder, seasonal affective disorder (SAD), and to help people quit smoking.

How does Wellbutrin SR work?

Wellbutrin SR works by increasing the levels of certain neurotransmitters in the brain, such as dopamine and norepinephrine, which helps regulate mood and improve symptoms of depression.

How should I take Wellbutrin SR?

Wellbutrin SR should be taken orally, with or without food, once or twice daily as prescribed by your healthcare provider. It's important to take Wellbutrin SR exactly as directed and not to change your dose or stop taking the medication without talking to your healthcare provider first.

What are the possible side effects of Wellbutrin SR?

Common side effects of Wellbutrin SR include dry mouth, trouble sleeping, agitation, headache, and nausea. Some serious side effects can also occur, such as seizures, angina (chest pain), and thoughts of suicide. If you experience any of these symptoms, it is important to seek medical attention right away.

Can I drink alcohol while taking Wellbutrin SR?

It is not recommended to drink alcohol while taking Wellbutrin SR, as it can increase the risk of certain side effects and impair judgment and motor skills. You should always talk to your healthcare provider about alcohol use and any other substances you may be taking while on Wellbutrin SR.

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JudithNovember 30, 2022

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EdwardSeptember 29, 2022

I had wonderful service as I have every time I’ve dealt with you. My questions were answered promptly and I received my medication right on time. Thank you so much.

LindaSeptember 29, 2022

A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

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