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IMPORTANT NOTE: A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.
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Buy Vagifem (Estradiol) Online

Buying Vagifem has never been easier. Buying medication from Canada Pharmacy Depot is quick, efficient and affordable. Order online or call us today and we will ship your prescription and over the counter medications directly to your door saving you long lines and unnecessary hassle going to your local pharmacy as well as up to 90% of the cost of your medication.

What is Vagifem?

Vagifem contains Estradiol and is a female hormone medication which is used to treat the vaginal symptoms of menopause such as vaginal dryness, burning, itching and painful sexual intercourse. These symptoms are a result of the body making less estrogen which is a female sex hormone that regulates many body processes.

Always read the patient information and instructions carefully before using this medication.

  • Vagifem is usually taken once a day for the first two weeks of treatment and twice weekly after that.
  • Vagifem comes as individual applicators preloaded with a tablet inside.
  • Gently insert the applicator into your vagina and push down the plunger in order to release the medication.
  • If the tablet falls out before it is used, then discard it and use a new applicator.
  • Your Vagifem dosage is based on your response to treatment and medical condition. Do not change your dosage or the frequency taken unless you are directed by a doctor.
  • Vagifem is most effective when it is used regularly. Always follow your dosing schedule. Inform your doctor if your condition worsens or does not improve.


Make sure to tell your doctor and pharmacist:

  • If you have any drug allergies.
  • Which other prescription and non-prescription medications you currently take.
  • Your medical history especially of kidney disease, liver disease, heart disease, heart attack, seizures, migraines, asthma, high blood pressure, diabetes, blood clotting disorders, stroke, obesity, lupus, underactive thyroid, obesity, porphyria, mental or mood disorders, uterus problems, mineral imbalance, hypoparathyroidism, gallbladder disease, vaginal bleeding, cancer or high cholesterol levels.
  • Your personal and family history of cancer, blood clots, breast lumps and angioedema.
  • If you have had recent surgery, will be having surgery or will be confined to a bed or chair for a long time, such as on a long flight. These conditions can increase the likelihood of blood clots and you may need to temporarily stop taking Vagifem.

Also be aware that:

  • You should not smoke or use tobacco while using Vagifem. This can further increase the chance of heart attack, high blood pressure, blood clots or strokes especially if you are over 35.
  • This medication may cause blotchy, dark areas to appear on your skin or face. This effect may be worsened by sunlight. Therefore, you should limit your time in the sun, wear protective clothing and use sunscreen when needed. Avoid using tanning booths and sunlamps.
  • If you are nearsighted or if you wear contact lenses, you may develop vision problems.
  • Vagifem should not be used during pregnancy.

Vagifem Side Effects

Common side effects of Vagifem may include but are not limited to:

  • Nausea, vomiting or diarrhea.
  • Weight changes or bloating.
  • Breast tenderness.
  • Headaches.

Contact your doctor if you experience any of the following Vagifem side effects:

  • Severe stomach or abdominal pain, persistent vomiting or nausea.
  • Memory loss, depression or other mental or mood changes.
  • Breast lumps.
  • New or increased vaginal irritation, bleeding, odor, itching or discharge.
  • Jaundice.
  • Swelling of the hands or feet.
  • Increased thirst.
  • Increased or dark urine.
  • Signs of a blood clot such as vision changes, confusion, sudden dizziness, fainting, unusual sweating, slurred speech, sudden or severe headache, coughing up blood, weakness or numbness in your arms or legs, breathing problems, pain in your chest, jaw or left arm, weakness on one side of the body, tingling or pain, redness or swelling of the legs.
  • Signs of an allergic reaction such as hives, hitching of the face, tongue or throat, dizziness or breathing trouble.


Is there a Vagifem generic alternative?

There is currently no therapeutically equivalent generic alternative to Vagifem.

How do I use Vagifem?

Gently insert a Vagifem applicator into the vagina and push down on the plunger to release the medication.

A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

Your Lowest Price, Guaranteed

Our goal is to bring you the most affordable medication. If you find a lower price advertised by another website or your local pharmacy, we’ll match that price or beat it by 10% of the difference.* Call us at 1-877-204-1507 and a member of our CareTeam will be happy to assist you.

Call 1-877-204-1507
* Some exceptions may apply
Some exceptions may apply. To qualify for price matching, competitors must meet our standards for patient safety. Advertised prices must be for medication of the same type, strength, quantity, and form.

Real Customers, Honest Reviews

Great service, pricing and responsive
Lynne August 31, 2021

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Excellent 1st time service!
Harry August 30, 2021

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Excellent experience. Friendly, convenient and professional.
Patrick August 30, 2021

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Great customer service and good value compared to drug cost here in the US
Patti Ann August 1, 2021

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Canada Pharmacy Depot is truly one of the best and last places where I can experience truly customer-focused SERVICE! Your staff are always very professional, friendly, knowledgeable, and reliable. I am now old enough to remember when this sort of service was common in the United States. No longer. Thank you for not only providing excellent access to expensive prescriptions, but also a reminder that professionals DO still exist.
Valerie July 27, 2021

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Very easy, smooth & financially worthwhile transaction. Will definitely return to reorder in a couple of months.
Stephen July 26, 2021

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First time customer, a little hesitant. It worked out great. Big savings on script.
raymond July 16, 2021

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I have been really pleased with the service I have gotten. Thank you for fabulous service and timely every time.
Nancy July 15, 2021

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good price compared to US medication
christiane August 30, 2021

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The customer service was really good, but I was very disappointed with how long it took to receive my medicine. Generally, when someone needs medicine, it is important that they get it pretty quick.
Faigy July 15, 2021
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