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Prescription Required
IMPORTANT NOTE: A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.
Difference between Brand & Generic?

Buy Vagifem (Estradiol) Online

Buying Vagifem has never been easier. Buying medication from Canada Pharmacy Depot is quick, efficient and affordable. Order online or call us today and we will ship your prescription and over the counter medications directly to your door saving you long lines and unnecessary hassle going to your local pharmacy as well as up to 90% of the cost of your medication.

What is Vagifem?

Vagifem contains Estradiol and is a female hormone medication which is used to treat the vaginal symptoms of menopause such as vaginal dryness, burning, itching and painful sexual intercourse. These symptoms are a result of the body making less estrogen which is a female sex hormone that regulates many body processes.

Always read the patient information and instructions carefully before using this medication.

  • Vagifem is usually taken once a day for the first two weeks of treatment and twice weekly after that.
  • Vagifem comes as individual applicators preloaded with a tablet inside.
  • Gently insert the applicator into your vagina and push down the plunger in order to release the medication.
  • If the tablet falls out before it is used, then discard it and use a new applicator.
  • Your Vagifem dosage is based on your response to treatment and medical condition. Do not change your dosage or the frequency taken unless you are directed by a doctor.
  • Vagifem is most effective when it is used regularly. Always follow your dosing schedule. Inform your doctor if your condition worsens or does not improve.


Make sure to tell your doctor and pharmacist:

  • If you have any drug allergies.
  • Which other prescription and non-prescription medications you currently take.
  • Your medical history especially of kidney disease, liver disease, heart disease, heart attack, seizures, migraines, asthma, high blood pressure, diabetes, blood clotting disorders, stroke, obesity, lupus, underactive thyroid, obesity, porphyria, mental or mood disorders, uterus problems, mineral imbalance, hypoparathyroidism, gallbladder disease, vaginal bleeding, cancer or high cholesterol levels.
  • Your personal and family history of cancer, blood clots, breast lumps and angioedema.
  • If you have had recent surgery, will be having surgery or will be confined to a bed or chair for a long time, such as on a long flight. These conditions can increase the likelihood of blood clots and you may need to temporarily stop taking Vagifem.

Also be aware that:

  • You should not smoke or use tobacco while using Vagifem. This can further increase the chance of heart attack, high blood pressure, blood clots or strokes especially if you are over 35.
  • This medication may cause blotchy, dark areas to appear on your skin or face. This effect may be worsened by sunlight. Therefore, you should limit your time in the sun, wear protective clothing and use sunscreen when needed. Avoid using tanning booths and sunlamps.
  • If you are nearsighted or if you wear contact lenses, you may develop vision problems.
  • Vagifem should not be used during pregnancy.

Vagifem Side Effects

Common side effects of Vagifem may include but are not limited to:

  • Nausea, vomiting or diarrhea.
  • Weight changes or bloating.
  • Breast tenderness.
  • Headaches.

Contact your doctor if you experience any of the following Vagifem side effects:

  • Severe stomach or abdominal pain, persistent vomiting or nausea.
  • Memory loss, depression or other mental or mood changes.
  • Breast lumps.
  • New or increased vaginal irritation, bleeding, odor, itching or discharge.
  • Jaundice.
  • Swelling of the hands or feet.
  • Increased thirst.
  • Increased or dark urine.
  • Signs of a blood clot such as vision changes, confusion, sudden dizziness, fainting, unusual sweating, slurred speech, sudden or severe headache, coughing up blood, weakness or numbness in your arms or legs, breathing problems, pain in your chest, jaw or left arm, weakness on one side of the body, tingling or pain, redness or swelling of the legs.
  • Signs of an allergic reaction such as hives, hitching of the face, tongue or throat, dizziness or breathing trouble.


Is there a Vagifem generic alternative?

There is currently no therapeutically equivalent generic alternative to Vagifem.

How do I use Vagifem?

Gently insert a Vagifem applicator into the vagina and push down on the plunger to release the medication.

A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

Your Lowest Price, Guaranteed

Our goal is to bring you the most affordable medication. If you find a lower price advertised by another website or your local pharmacy, we’ll match that price or beat it by 10% of the difference.* Call us at 1-877-204-1507 and a member of our CareTeam will be happy to assist you.

Call 1-877-204-1507
* Some exceptions may apply
Some exceptions may apply. To qualify for price matching, competitors must meet our standards for patient safety. Advertised prices must be for medication of the same type, strength, quantity, and form.

Real Customers, Honest Reviews

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Maria February 5, 2021

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Hello, as a retired USA pharmacist, I can say that Canada Pharmacy Depot has 2 awesome points in my book. Number 1 is the saving cost. If I use my Medicare D plan, I'm into the "coverage gap" in January. It amazes me how over priced the USA system is, sad I have to say that, but it is totally true. Point Number 2 is your customer service. I used to try to go out of my way for patients. I'm definitely glad seeing the staff at Canada Pharmacy Depot embodies that same desire....KUDOS... Paul
Paul February 27, 2020

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I was very satisfied with the service and knowledge of your staff. Very professional and friendly. This was my first order and I felt very comfortable dealing with your pharmacy. I was walked through every step and my questions were answered.
Susan February 21, 2020

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I was very satisfied with your information about how to set up my account. Thanks!
Neoma February 21, 2020

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Wonderful service. Appreciate that you try to keep costs as low as you can.
Carolyn February 19, 2020

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Once the details were done setting up the account, the follow up on keeping me posted on the order was excellent. The prescription came well within the expected delivery date. Will be following up shortly for my refill.
Roslyn February 19, 2020

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I have not yet received the meds yet, but so far my experience with your reps has been fantastic! Very smart, very friendly and understanding. She was a great representative who explained the details and put my mind at ease.
Barbara February 18, 2020

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George February 18, 2020

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I have not used the Canada Pharmacy Depot prior to this order. I was pleased that you did a price match and the order was managed quickly and efficiently after providing the necessary prescription. I will use the CPD again! Don
Donald January 30, 2020

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The Canada Pharmacy Depot exceeded my expectations. They made it easy to send them the Rx and the wait time was not long before my order arrived.
ROBERT October 20, 2019
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