Trintellix is an FDA-approved medication used to treat major depressive disorder (MDD) in adults. It belongs to a class of drugs called atypical antidepressants, which are prescribed when other antidepressants have not worked. However, Trintellix may also be used as a first-line treatment, depending on a person's symptoms and medical history.

Trintellix treats depression by balancing neurotransmitters in the brain, especially serotonin. Experts believe it enhances serotonin activity by blocking the reabsorption of serotonin, leaving more available to transmit signals between neurons. 

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When you start taking Trintellix, your doctor will prescribe the lowest effective dosage for you. The goal is to find the smallest amount of medication that helps improve your depressive symptoms.

The typical starting dose of Trintellix is 10 mg once daily. This low initial dose helps minimize potential side effects as your body gets used to the medication.

If the 10 mg dose does not fully relieve your depression after some time, your doctor may increase your dosage to 20 mg once daily. The higher dose may provide the extra benefit you need.

However, if the 10 mg dose causes unpleasant side effects, your doctor may decrease your Trintellix dosage to 5 mg once daily. The lower dose could reduce side effects while still helping with your depression.

These recommended dosages for Trintellix come from the FDA, but your doctor will tailor your prescription to your needs.

Trintellix may cause some temporary side effects as your body adjusts to the drug. These side effects usually only last a few days or weeks. However, if any side effects continue for longer than that or become severe, be sure to consult your doctor right away.

Some common side effects that you may experience when first starting Trintellix include:

• Constipation
• Diarrhea
• Dry mouth
• Nausea
• Vomiting
• Dizziness
• Nausea
• Itching
• Mild allergic reaction

Trintellix can interact with some medications, so it’s important to let your doctor know about any other medications you’re taking. Certain drugs may impact the level of Trintellix or serotonin in your body, requiring an adjusted dosage to ensure effectiveness and safety.

• Monoamine oxidase inhibitors (MAOIs): Do not take Trintellix within 14 days of stopping an MAOI antidepressant or start an MAOI within 21 days after stopping Trintellix. Using these medications together increases the risk of serotonin syndrome, which causes dangerous symptoms like high fever, stiff muscles, confusion, and seizures.

• Serotonergic drugs: Taking Trintellix alongside other serotonergic medications that increase serotonin levels can also increase the risk of serotonin syndrome. Your doctor will monitor you more closely for symptoms if this combination is necessary.

• CYP2D6 inhibitors: Medications called CYP2D6 inhibitors prevent Trintellix from being properly broken down in the body, leading to higher than intended levels in the bloodstream. This further raises the risk of serotonin syndrome. If you are taking CYP2D6 inhibitors, your doctor may adjust your Trintellix dosage accordingly.

• CYP inducers: These medications speed up the breakdown of Trintellix, potentially making it less effective. If you are also taking CYP inducers, your doctor may increase your Trintellix dosage.

• Blood thinners: Taking Trintellix with blood thinners may increase the chance of stomach bleeding. In this case, your doctor will closely monitor your international normalized ratio (INR). The INR value shows how long it takes for your blood to clot. 

What is Trintellix used for?

Trintellix is a prescription antidepressant medication approved by the FDA to treat major depressive disorder (MDD) in adults.

How does Trintellix work?

Trintellix works by helping to restore balance to neurotransmitter activity in the brain. Neurotransmitters like serotonin are chemical messengers that allow neurons to communicate with each other.

In people with depression, there may be an imbalance in serotonin signaling. Trintellix aims to correct this imbalance by blocking serotonin's reabsorption (reuptake). This leaves more free serotonin in the brain to bind to receptors and transmit messages between neurons.

How do I take Trintellix?

Trintellix should be taken orally, with or without food, once daily as prescribed by your healthcare provider. It's important to take Trintellix exactly as your doctor has directed. Do not stop taking Trintellix or change your dose without talking to your doctor first. Doing so can cause unwanted side effects or withdrawal symptoms.

What should I do if I miss a dose of Trintellix?

If you miss a dose of Trintellix, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for the missed one.

How long does it take for Trintellix to work?

In short-term clinical studies lasting 6 to 8 weeks, Trintellix began relieving symptoms of depression as early as week 2. However, it took approximately 4 weeks or more for study participants to experience the medication's full effects.