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IMPORTANT NOTE: A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.
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Buy Synthroid (Levothyroxine) Online

It has never been easier to buy your prescription medications online. Canada Pharmacy Depot lets you buy Synthroid quickly and for a fraction of the cost you are used to paying in the US. Order online today or call us 7 days a week.

What is Synthroid?

Synthroid (Levothyroxine) is a medication used to treat hypothyroidism. Hypothyroidism is a condition where the thyroid gland does not produce enough thyroid hormone. Levothyroxine works by replacing the thyroid hormone which is normally produced by the body and can treat symptoms such as poor growth, constipation, weight gain, slow speech, hair loss, lack of energy, excessive tiredness, dry or thick skin, increased sensitivity to cold, muscle and joint pain, heavy or irregular menstrual periods and depression.

Always read the patient information and instructions carefully before using this medication. Follow your doctor’s directions.

  • Levothyroxine is usually taken once daily. It should be taken on an empty stomach between 30 and 60 minutes before breakfast.
  • You should swallow Synthroid capsules whole without chewing or crushing. Swallow the capsules with a full glass of water.
  • If you cannot swallow Synthroid whole, crush and mix it into 5 to 10ml (1 or 2 teaspoons) of water and take it immediately.
  • Your doctor may start you on a low dose and gradually increase it.
  • It may take several weeks before you notice a change in your symptoms. Continue taking this medication even if you feel well.


Make sure to tell your doctor and pharmacist:

  • If you have any drug or other allergies.
  • Which other prescription and non-prescription medications you currently take.
  • Your medical history especially of adrenal insufficiency, diabetes, bleeding problems, porphyria, hardening of the arteries, osteoporosis, pituitary gland disorders, kidney disease, heart disease, liver disease or any condition which makes it difficult to swallow.
  • If you are pregnant, planning on pregnancy or breast feeding.
  • If you have recently received radiation therapy with iodine.

Also be aware that:

  • You should make all of your doctors and dentists aware that you take Synthroid before any surgery, dental surgery or emergency procedures.

Side effects of Synthroid

Common side effects of Synthroid may include but are not limited to:

  • Headaches.
  • Muscle weakness or leg cramps.
  • Trouble sleeping or nervousness.
  • Diarrhea.
  • Skin rashes.

Contact your doctor if you experience any of the following levothyroxine side effects:

  • Shortness of breath
  • Sweating, feeling unusually cold, fever or hot flashes.
  • Tremors.
  • Vomiting or diarrhea.
  • Skin or hair dryness.
  • Hair loss.
  • Chest pain or fast or irregular heartbeats.
  • Weakness, tiredness or sleep problems such as insomnia.
  • Memory problems, feeling irritable or depressed.
  • Changes in your menstrual periods.
  • Appetite changes or weight changes.
  • Signs of an allergic reaction such as hives, difficulty breathing or a swelling of your face, lips or throat.


What should I do if I miss a dose of Synthroid?

If you miss a dose of this medication, take it as soon as you remember. If it is almost time for your next dose, then skip your missed dose.

What should I avoid while taking Synthroid?

While taking Synthroid, you should avoid grapefruit juice, cotton seed meal, walnuts, soybean flower, instant soybean formula and other high fiber foods as these products may make your body absorb less medication.

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Real Customers, Trustworthy Reviews

Read what others have to say before you buy — honest reviews from real people.


JudithNovember 30, 2022

Great job! Very reasonable prices and fast service

KathleenOctober 5, 2022

Good experience.

ElizabethSeptember 30, 2022

Great service and very timely.

ChrisSeptember 30, 2022

Great service from start to finish.

EdwardSeptember 29, 2022

I had wonderful service as I have every time I’ve dealt with you. My questions were answered promptly and I received my medication right on time. Thank you so much.

LindaSeptember 29, 2022

A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

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Our goal is to bring you the most affordable medication. If you find a lower price advertised by another website or your local pharmacy, we’ll match that price or beat it by 10% of the difference.* Call us at 1-877-204-1507 and a member of our CareTeam will be happy to assist you.

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Some exceptions may apply. To qualify for price matching, competitors must meet our standards for patient safety. Advertised prices must be for medication of the same type, strength, quantity, and form.