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Canada Pharmacy Depot Prescription Required
IMPORTANT NOTE: A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.
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  • Delivery time is between 8-14 business days.
  • Express shipping may be available upon request

What is Simbrinza?

Simbrinza is a medication used to treat high eye pressure for those with glaucoma or ocular hypertension. This medication works best for open-angle glaucoma. Simbrinza reduces the risk of vision loss, nerve damage, and blindness with those with high eye pressure. Simbrinza is a carbonic anhydrase inhibitor that works by decreasing the amount of fluid in the eye. Less fluid reduces the pressure in the eye and improves glaucoma symptoms.

Always read the medication instructions before using this medication.
Always follow your doctor’s directions.

  • Shake the bottle well before each dose and remove content lenses before using eye drops.
  • Do not touch the dropper tip to your eye
  • Tilt your head back and look upward, pulling down the lower lid to create a pouch. Hold the dropper above the eye and place a drop in the pouch.
  • Look downward and close your eyes, placing one finger at the corner of your eye near the nose.
  • Apply pressure to this area for one to two minutes
  • Repeat this step for the other eye
  • Do not rinse the dropper tip

Cautions

Make sure to tell your doctor:

  • If you have any drug or other allergies.
  • If you regularly drink alcohol or consume marijuana products
  • If you take any other prescription or over-the-counter medications.
  • If you have a medical history of blood vessel diseases, heart disease, kidney disease, liver disease, or low blood pressure.
  • Your vision may become temporarily blurred after use, so do not drive or use machinery until you can do it safely.
  • If you are pregnant or planning on pregnancy.
  • If you are breast-feeding.

Side Effects of Simbrinza

Common side effects of Simbrinza:

  • Eye discomfort (itching, redness, and discharge)
  • Dry eyes
  • Feeling like something is in your eye
  • Dry mouth
  • Dry eyes
  • Bitter taste in your mouth
  • Dizziness
  • Drowsiness
  • Tiredness
  • Headache

If you have any of the following side effects, seek medical help:

  • Fainting
  • Slow or irregular heartbeat
  • Signs of an allergic reaction (swelling of the face, tongue, or throat)
  • Trouble breathing

FAQs

How often should Simbrinza be used?

Always follow your doctor's instructions when starting a new medication. Generally. Simbrinza is used three times a day to prevent glaucoma. You cannot overdose on Simbrinza, but it is harmful if swallowed.

Can I use other eye drops if I’m using Simbrinza?

Yes! If you are using another kind of eye medication, wait at least 5 minutes after using Simbrinza to use your other eye drops.

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Real Customers, Trustworthy Reviews

Read what others have to say before you buy — honest reviews from real people.

We have had very good service from the Canada Pharmacy Depot, obtaining a very expensive medication (in the USA) for the very same medication from India for a fraction of the US cost ($488/3mo supply vs $1400/1mo supply). This has been a godsend bc my husband has Parkinson's Disease and takes many medications to manage his condition. It does take longer to get the medication, but you just have to plan ahead for significant savings.

JoyceJanuary 29, 2026

So nice and easy to order and arrange payment by phone...especially for this OLD person who is "computer resistive(illiterate)"

PeterJanuary 25, 2026

I called with the purpose of refilling my order. The person I interacted with was polite, careful, and efficient. Very well organized and fastidious about verifying the details of my order and payment.

CharlesJanuary 22, 2026

The Canadian Depot Pharmacy always updates me on my orders. Easy to use and a big cost savings.

DebbieJanuary 20, 2026

Outstanding customer service and courtesy. Thank you for helping to resolve my issue with my order for Eliquis.

DonnaJanuary 16, 2026

Always excellent and a pleasure!

JosephJanuary 15, 2026

A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

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Our goal is to bring you the most affordable medication. If you find a lower price advertised by another website or your local pharmacy, we’ll match that price or beat it by 10% of the difference.* Call us at 1-877-204-1507 and a member of our CareTeam will be happy to assist you.

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* Some exceptions may apply
Some exceptions may apply. To qualify for price matching, competitors must meet our standards for patient safety. Advertised prices must be for medication of the same type, strength, quantity, and form.