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What is Progesterone?

Progesterone and the brand name Prometrium are female hormones that are important to regulate ovulation and menstruation. This medication is used to cause menstrual periods in women who are yet to reach menopause but are not having periods due to a lack of progesterone in their bodies. Prometrium may also be used to prevent overgrowth of the uterus lining in postmenopausal women receiving estrogen hormone replacement therapy.

Always read the patient information and instructions carefully before using this medication. Follow your doctor’s directions.

• Prometrium capsules should be taken with a full glass of water.
• Take progesterone at night as it can cause dizziness or drowsiness.
• While taking this medication, you should self-examine your breasts on a monthly basis and have regular physical exams.
• Follow your doctor’s dosing schedule carefully. It is sometimes only taken for a short time.

Make sure to tell your doctor and pharmacist:

• If you have any drug or other allergies.
• Which other prescription and non-prescription medications you currently take.
• Your medical history especially of abnormal vaginal bleeding, breast cancer, liver disease, stroke, heart attack, heart disease, migraines, asthma, kidney disease, seizures, epilepsy, blood clots, depression, high blood pressure, diabetes, lupus or high cholesterol.
• If you have recently had an incomplete miscarriage or “missed” abortion.
• If you have risk factors for coronary heart disease including a family history of coronary heart disease, smoking or if you are overweight.
• If you are breast feeding.

Also be aware that:

• You may need to temporarily stop taking progesterone
• Prometrium should not be used if you are pregnant as it may harm an unborn baby.
• Using progesterone may increase your risk of stroke, heart attack, breast cancer or blood clots.

Common Prometrium side effects may include but are not limited to:

• Nausea or bloating.
• Breast tenderness.
• Changes in vaginal discharge.
• Headache.
• Dizziness or drowsiness.
• Blurred vision.
• Mood swings.

Contact your doctor if you experience any of the following side effects of progesterone:

• Unusual vaginal bleeding such as spotting or breakthrough bleeding.
• Mental or mood changes such as memory loss or depression.
• Sudden severe headaches or chest, jaw or left arm pain.
• Pain, redness, swelling or weakness in the arms or legs.
• Calf pain or swelling which is warm to the touch.
• Confusion, severe dizziness or slurred speech.
• Dark patches on the skin or face.
• Unusual tiredness.
• Persistent nausea or vomiting.
• Fainting.
• Coughing up blood.
• Trouble breathing.
• Breast lumps.
• Swelling in the hands or feet.
• Bulging eyes or vision changes such as blurred vision, double vision or loss of vision.
• Stomach or abdominal pain.
• Frequent, burning, dark or painful urination.
• Jaundice.
• Weakness on one side of the body.
• Difficulty walking.
• Signs of an allergic reaction such as hives, difficulty breathing or a swelling of your face, lips or throat.

What should I do if I miss a dose of Prometrium?

If you miss a dose of this medication, take it as soon as you remember. If it is almost time for your next dose, then skip your missed dose. Call your doctor if you miss more than one dose.

What else is Prometrium called?

Prometrium is also known as Utrogestan. Utrogestan is not a generic alternative but the same brand name medication with a different name internationally. The generic alternative to Prometrium is known as progesterone or progesterone micronised.