Chat with us, powered by LiveChat
Canada Pharmacy Depot Prescription Required
IMPORTANT NOTE: A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.
Available 7 Days a Week


Express shipping

May be available upon request

Lowest Price, Guaranteed

match price or beat it by 10% *

Life-Time Free shipping

Find out if you're eligible!

  • Delivery time is between 8-14 business days.
  • Express shipping may be available upon request

Buy Pristiq ER (Desvenlafaxine ER) Online

Are you looking to buy Pristiq ER and other prescription medications for a fraction of what you usually pay? Buying medications with Canada Pharmacy Depot can save you up to 90% on the cost of Pristiq ER. It’s safe, convenient and quick from a reputable Canadian pharmacy and you can order online or call us 7 days a week.

What is Pristiq ER?

Pristiq ER (desvenlafaxine) is an anti-depressant medication which is used to treat major depressive disorder. Desvenlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI) which helps to restore the balance of natural substances serotonin and norepinephrine in the brain. Pristiq ER can improve your mood, energy level and feelings of well-being.

Always read the patient information and instructions carefully before using this medication. Follow your doctor’s directions.

  • Pristiq ER should be taken with water either with or without food. Take Pristiq ER at the same time each day.
  • Pristiq ER tablets should be swallowed whole without chewing, crushing or breaking.
  • Your blood pressure will need to be checked regularly when taking this medication.
  • It may take several weeks before your symptoms improve. Continue taking Pristiq ER and do not stop taking this medication without speaking to your doctor.


Make sure to tell your doctor and pharmacist:

  • If you have any drug or other allergies.
  • Which other prescription and non-prescription medications you currently take.
  • Your medical history especially of heart disease, stroke, high blood pressure, high cholesterol, bleeding disorders, blood clotting disorders, liver disease, kidney disease, depression, suicidal thoughts, bipolar disorder, seizures, epilepsy, glaucoma, lung or breathing problems or low levels of sodium in your blood.
  • If you are pregnant or planning pregnancy. Taking Pristiq late in pregnancy can increase the risk of excessive bleeding after giving birth.
  • If you are breast feeding.

Also be aware that:

  • You should not use Pristiq with 7 days before or 14 days after using an MAO inhibitor such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.
  • Some young people may have suicidal thoughts when initially taking an antidepressant. Stay alert to mood or symptoms changes.
  • You should avoid drinking alcohol while taking this medication.
  • Pristiq is not approved for use in those under 18 years old.

Pristiq ER side effects

Common Pristiq ER side effects may include but are not limited to:

  • Drowsiness or trouble sleeping.
  • Dizziness.
  • Nausea.
  • Dry mouth.
  • Constipation.
  • Loss of appetite or weight loss.
  • Blurred vision
  • Nervousness.
  • Excessive sweating.

Contact your doctor if you experience any of the following side effects of Pristiq ER:

  • Severe or pounding headache.
  • Easy bruising or bleeding.
  • Shakiness.
  • Changes in sexual activity or decreased interest in sex.
  • Coughing that doesn’t go away.
  • Shortness of breath.
  • Eye pain, swelling or redness, widened pupils or vision changes such as seeing rainbows around lights at night.
  • Chest pain.
  • Black stools or vomit which look like coffee grounds.
  • Seizures.
  • Signs of serotonin syndrome such as severe nausea, severe vomiting or severe diarrhea, unexplained fever, unusual agitation, restlessness, fast heartbeat, hallucinations, loss of coordination or severe dizziness.
  • Signs of an allergic reaction such as hives, difficulty breathing or a swelling of your face, lips or throat.


What should I do if I miss a dose of Pristiq ER?

If you miss a dose of this medication, take it as soon as you remember. If it is almost time for your next dose, then skip your missed dose.

How long does it take desvenlafaxine to work?

It may take several weeks before you feel the full benefit of this medication. Continue to take it regularly.

Hear From People Like You

Don't just take our word, listen to real customers whose lives have changed for the better.

Real Customers, Trustworthy Reviews

Read what others have to say before you buy — honest reviews from real people.


JudithNovember 30, 2022

Great job! Very reasonable prices and fast service

KathleenOctober 5, 2022

Good experience.

ElizabethSeptember 30, 2022

Great service and very timely.

ChrisSeptember 30, 2022

Great service from start to finish.

EdwardSeptember 29, 2022

I had wonderful service as I have every time I’ve dealt with you. My questions were answered promptly and I received my medication right on time. Thank you so much.

LindaSeptember 29, 2022

A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

Your Lowest Price, Guaranteed

Our goal is to bring you the most affordable medication. If you find a lower price advertised by another website or your local pharmacy, we’ll match that price or beat it by 10% of the difference.* Call us at 1-877-204-1507 and a member of our CareTeam will be happy to assist you.

Call 1-877-204-1507
* Some exceptions may apply
Some exceptions may apply. To qualify for price matching, competitors must meet our standards for patient safety. Advertised prices must be for medication of the same type, strength, quantity, and form.