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What is Pristiq ER?

Pristiq ER (desvenlafaxine) is an anti-depressant medication which is used to treat major depressive disorder. Desvenlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI) which helps to restore the balance of natural substances serotonin and norepinephrine in the brain. Pristiq ER can improve your mood, energy level and feelings of well-being.

Always read the patient information and instructions carefully before using this medication. Follow your doctor’s directions.

• Pristiq ER should be taken with water either with or without food. Take Pristiq ER at the same time each day.
• Pristiq ER tablets should be swallowed whole without chewing, crushing or breaking.
• Your blood pressure will need to be checked regularly when taking this medication.
• It may take several weeks before your symptoms improve. Continue taking Pristiq ER and do not stop taking this medication without speaking to your doctor.

Make sure to tell your doctor and pharmacist:

• If you have any drug or other allergies.
• Which other prescription and non-prescription medications you currently take.
• Your medical history especially of heart disease, stroke, high blood pressure, high cholesterol, bleeding disorders, blood clotting disorders, liver disease, kidney disease, depression, suicidal thoughts, bipolar disorder, seizures, epilepsy, glaucoma, lung or breathing problems or low levels of sodium in your blood.
• If you are pregnant or planning pregnancy. Taking Pristiq late in pregnancy can increase the risk of excessive bleeding after giving birth.
• If you are breast feeding.

Also be aware that:

• You should not use Pristiq with 7 days before or 14 days after using an MAO inhibitor such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.
• Some young people may have suicidal thoughts when initially taking an antidepressant. Stay alert to mood or symptoms changes.
• You should avoid drinking alcohol while taking this medication.
• Pristiq is not approved for use in those under 18 years old.

Common Pristiq ER side effects may include but are not limited to:

• Drowsiness or trouble sleeping.
• Dizziness.
• Nausea.
• Dry mouth.
• Constipation.
• Loss of appetite or weight loss.
• Blurred vision
• Nervousness.
• Excessive sweating.

Contact your doctor if you experience any of the following side effects of Pristiq ER:

• Severe or pounding headache.
• Easy bruising or bleeding.
• Shakiness.
• Changes in sexual activity or decreased interest in sex.
• Coughing that doesn’t go away.
• Shortness of breath.
• Eye pain, swelling or redness, widened pupils or vision changes such as seeing rainbows around lights at night.
• Chest pain.
• Black stools or vomit which look like coffee grounds.
• Seizures.
• Signs of serotonin syndrome such as severe nausea, severe vomiting or severe diarrhea, unexplained fever, unusual agitation, restlessness, fast heartbeat, hallucinations, loss of coordination or severe dizziness.
• Signs of an allergic reaction such as hives, difficulty breathing or a swelling of your face, lips or throat.

What should I do if I miss a dose of Pristiq ER?

If you miss a dose of this medication, take it as soon as you remember. If it is almost time for your next dose, then skip your missed dose.

How long does it take desvenlafaxine to work?

It may take several weeks before you feel the full benefit of this medication. Continue to take it regularly.