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What is Prempro?

Prempro contains a combination of conjugated estrogens and medroxyprogesterone and is used to treat symptoms of menopause such as vaginal changes and hot flashes. Prempro can also be used to prevent osteoporosis in menopausal women. Estrogen is a female sex hormone that is naturally produced in the ovaries and is necessary for many body processes. Medroxyprogesterone is a form of progesterone which is a female hormone that is important for regulating menstruation and ovulation.

Always read the patient information and instructions carefully before using this medication. Follow your doctor’s directions.

• Prempro should be taken at the same time each day. Your doctor may direct you to take Prempro alone or with other medications.
• See your doctor for regular checks while taking Prempro.
• Self-examine your breasts monthly and have regular mammograms.
• Tell your doctor if you will be having major surgery or if you will be on long-term bed rest. You may need to temporarily stop taking Prempro.

Make sure to tell your doctor and pharmacist:

• If you have any drug or other allergies.
• Which other prescription and non-prescription medications you currently take.
• Your medical history especially of unusual vaginal bleeding, liver disease, bleeding disorders, heart disease, heart attack, stroke, blood clots, cancer, high blood pressure, high cholesterol, hysterectomy, jaundice, kidney disease, gallbladder disease, asthma, epilepsy, migraines, lupus, endometriosis, uterine fibroid tumors, porphyria, thyroid disorder, high levels of calcium in your blood or diabetes.
• Your family and personal history of angioedema.
• If you will be having major surgery.
• If you are overweight or if you smoke as these factors may increase your risk of blood clots, heart attack or stroke.
• If you are breast feeding.

Also be aware that:

• Prempro should not be used if you are pregnant.

Common Prempro side effects may include but are not limited to:

• Stomach upset, nausea or vomiting.
• Bloating or weight changes.
• Breast tenderness.
• Headaches.

Contact your doctor if you experience any of the following side effects of Prempro:

• Mental or mood changes such as depression or memory loss.
• Unusual vaginal bleeding such as spotting, breakthrough bleeding, prolonged or recurrent bleeding.
• Breast lumps
• New or increased vaginal itching, odor, discharge or irritation.
• Severe stomach or abdominal pain.
• Persistent vomiting or nausea.
• Increased thirst or urination.
• Jaundice.
• Sudden or severe headaches.
• Dark urine.
• Swelling of the hands, ankles or feet.
• Pain in your chest, jaw or left arm.
• Unusual sweating.
• Coughing up blood.
• Sudden dizziness or fainting.
• Confusion or slurred speech.
• Pain, redness or swelling of the legs.
• Sudden vision changes such as partial or complete blindness.
• Tingling, numbness or weakness in the arms or legs.
• Trouble breathing.
• Signs of an allergic reaction such as hives, difficulty breathing or a swelling of your face, lips or throat.

What should I do if I miss a dose of Prempro?

If you miss a dose of this medication, take it as soon as you remember. If it is almost time for your next dose, then skip your missed dose.

What else is Prempro called?

Prempro is also known as Premique. Premique is not a generic alternative but the same brand name medication with a different name internationally.