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What is Premarin Cream?

Premarin Cream is a vaginal medication containing a mixture of estrogen hormones and is prescribed to treat vaginal symptoms of menopause including vaginal dryness, burning, irritation and painful sexual intercourse. These symptoms are caused when the body makes less estrogen itself. Premarin Cream may also be prescribed to treat kraurosis vulvae.

Always read the patient information and instructions carefully before using this medication. Follow your doctor’s directions.

• You should only use Premarin Cream with the applicator provided. It is usually applied on a schedule which alternates several weeks with the cream being applied daily and then one week where the cream is not applied.
• Screw the applicator onto the tube of cream and fill the applicator with the correct dosage of cream before unscrewing the applicator.
• Lie on your back with your knees up towards your chest and gently insert the applicator into your vagina. Push the plunger downwards to release the cream and then remove the applicator from your vagina.
• Take the applicator apart and clean it with mild soap and warm water after each use. Do not use hot or boiling water to clean.
• Your doctor should check your progress on a regular basis. Every month, self-examine your breasts for lumps and have regular mammograms.
• Premarin Cream is most effective when it is taken regularly. Try to take this medication at the same time each day. Tell your doctor if your condition does not improve or worsens.

Make sure to tell your doctor and pharmacist:

• If you have any drug or other allergies.
• Which other prescription and non-prescription medications you currently take.
• Your medical history especially of heart attack, heart problems, heart disease, migraines, lupus, endometriosis, uterine fibroid tumors, hereditary blood disorders, unusual vaginal bleeding, liver disease, asthma, epilepsy, seizures, stroke, blood clots, cancer, a hysterectomy, jaundice, kidney disease, gallbladder disease, hereditary angioedema, porphyria, thyroid disorder or high levels of calcium in your blood.
• If you are breast feeding.

Also be aware that:

• You may need to stop using this medication if you need major surgery or will be on long-term bed rest.
• Premarin Cream should not be used during pregnancy. If you are not past menopause, use effective birth control. Talk to your doctor about the best birth control method to use as Premarin may weaken the latex of a condom, diaphragm or cervical cap.
• Premarin can increase the risk of blood clots, heart attack or stroke and this risk is increased if you are overweight, if you smoke or if you have diabetes, high blood pressure or high cholesterol.
• This medication should not be used by anyone younger than 18.

Common Premarin Cream side effects may include but are not limited to:

• Nausea or vomiting.
• Bloating or weight gain.
• Headaches.
• Breast tenderness.

Contact your doctor if you experience any of the following side effects of Premarin Cream:

• Mental or mood changes such as depression or memory loss.
• Breast lumps.
• New or increased vaginal irritation, discharge, itching or odor.
• Unusual vaginal bleeding including spotting, breakthrough bleeding, prolonged or recurring bleeding.
• Persistent nausea or vomiting.
• Severe stomach or abdominal pain.
• Jaundice.
• Increased urination or thirst.
• Swelling of your hands, feet or ankles.
• Signs of blood clot problems such as unusual sweating, sudden or severe headache, confusion, weakness on one side of the body, chest pain, jaw pain, left arm pain, slurred speech, trouble breathing, vision changes, leg pain, leg redness, leg swelling, sudden dizziness, fainting or a tingling, weakness or numbness in your arms or legs.
• Signs of an allergic reaction such as hives, difficulty breathing or a swelling of your face, lips or throat.

What should I do if I miss a dose of Premarin Cream?

If you miss a dose of this medication, take it as soon as you remember. If it is almost time for your next dose, then skip your missed dose.

What can increase the risk of blood clots while using Premarin Cream?

Premarin can increase the risk of blood clots, heart attack or stroke and this risk is increased if you are overweight, if you smoke or if you have diabetes, high blood pressure or high cholesterol.