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What is Estrace?

Estrace tablets and the generic alternative estradiol are medications used to treat vaginal changes, hot flashes and other menopausal symptoms caused by the body producing less estrogen. Estrace may also be used to prevent osteoporosis in menopausal women and to replace estrogen in women who have conditions which cause a lack of natural estrogen in the body such as ovarian failure. Estradiol is a female sex hormone which regulates many body processes.

Always read the patient information and instructions carefully before using this medication. Follow your doctor’s directions.

• Take Estrace by mouth. Taking Estrace tablets with food or after a meal can help to prevent stomach upset.
• Your doctor may want to check your progress on a regular basis.
• While taking Estrace, you should check your breasts for lumps on a monthly basis and have an annual mammogram.

Make sure to tell your doctor and pharmacist:

• If you have any drug or other allergies.
• Which other prescription and non-prescription medications you currently take.
• Your medical history especially of unusual vaginal bleeding, liver disease, liver problems, heart attack, heart disease, heart problems, stroke, blood clot, blood disorders, cancer, jaundice, kidney disease, gallbladder disease, asthma, epilepsy or other seizure disorders, migraines, lupus endometriosis, uterine fibroid tumors, porphyria, high blood pressure, high cholesterol, diabetes, thyroid disorders or high levels of calcium in your blood.
• If you have personal or family history of angioedema.
• If you smoke or if you are overweight.
• If you are breast feeding.

Also be aware that:

• Estrace should not be used if you are pregnant.

Common Estrace side effects may include but are not limited to:

• Diarrhea, vomiting, nausea or stomach cramps.
• Changes to menstrual periods, vaginal itching, discharge or breakthrough bleeding.
• Cold symptoms including stuffy nose, sore throat or sinus pain.
• Sleep problems.
• Mood changes.
• Weight gain.
• Headache, back pain or breast pain.
• Thinning scalp hair.

Contact your doctor if you experience any of the following side effects of Estrace:

• Stomach swelling or tenderness.
• Breast lumps.
• Unusual vaginal bleeding or pelvic pain.
• Jaundice.
• Memory problems, confusion or unusual behavior.
• Symptoms of a heart attack such as chest pain or pressure, nausea, sweating, or pain spreading to your jaw or shoulder.
• Symptoms of a stroke such as severe headache, slurred speech, problems with vision or balance, or sudden numbness or weakness especially on one side of the body.
• Symptoms of a blood clot such as sudden vision loss, stabbing chest pain, shortness of breath, coughing up blood or pain or warmth in one or both legs.
• Symptoms of high levels of calcium such as nausea, constipation, vomiting, increased urination or thirst, muscle weakness, lack of energy or bone pain.
• Signs of an allergic reaction such as hives, difficulty breathing or a swelling of your face, lips or throat.

What should I do if I miss a dose of Estrace?

If you miss a dose of this medication, take it as soon as you remember. If it is almost time for your next dose, then skip your missed dose.

What should I avoid while taking Estrace?

Avoid eating grapefruit and drinking grapefruit juice as they can lead to unwanted side effects. Avoid smoking as it can greatly increase your risk of blood clots, stroke and heart attack.