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Prescription Required
IMPORTANT NOTE: A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.
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Buy Efudex Cream (Fluorouracil Cream) Online

Are you looking to buy Fluorouracil Cream and other prescription medications for a fraction of what you usually pay? Buying medications with Canada Pharmacy Depot can save you up to 90% on the cost of Fluorouracil Cream. It’s safe, convenient and quick from our Canadian pharmacy and you can order online or call us 7 days a week.

What is Fluorouracil Cream?

Fluorouracil Cream and the brand name Efudex Cream are medications used to treat pre-cancerous and cancerous skin growths and scaly overgrowths of the skin. Fluorouracil interferes with the growth of skin cells and works by causing the death of cells which grow fastest such as abnormal skin cells.

Always read the patient information and instructions carefully before using this medication. Follow your doctor’s directions.

  • Clean and rinse the affected area and dry with a towel. Wait ten minutes before applying Efudex Cream.
  • Wash your hands before and after using this medication unless it is being used to treat a hand condition.
  • Use finger tips or a non-metal applicator to apply Efudex to the affected area. Use enough medication to cover the entire area with a thin film. Smooth the cream gently onto the affected skin.
  • Fluorouracil cream should not be applied to open wounds or skin which is irritated, infected or peeling.
  • Do not cover the treated skin area unless directed to by a doctor.
  • Wait two hours before applying moisturizer or sunscreen.


Make sure to tell your doctor and pharmacist:

  • If you have any drug or other allergies.
  • Which other prescription and non-prescription medications you currently take.
  • Your medical history especially of dihydropyrimidine dehydrogenase (DPD) enzyme deficiency.

Also be aware that:

  • This medication should not be used during pregnancy. Use effective birth control to prevent pregnancy while using fluorouracil cream. Ask your doctor about how long to prevent pregnancy after ending treatment.
  • You should not breast feed while using fluorouracil cream.
  • Efudex Cream should not be used by anyone under the age of 18.

Side effects of Efudex

Common Fluorouracil Cream side effects may include but are not limited to:

  • Skin irritation, burning, pain, redness, dryness, swelling, tenderness or changes in skin color at the site of application.
  • Trouble sleeping.
  • Eye irritation, stinging or watering.
  • Temporary hair loss.
  • Abnormal taste in the mouth.
  • Irritability.

Contact your doctor if you experience any of the following side effects of Efudex Cream:

  • Stomach or abdominal pain.
  • Bloody diarrhea.
  • Vomiting.
  • Mouth sores.
  • Easier bruising or bleeding.
  • Signs of infection such as fever, chills or a persistent sore throat.
  • Signs of an allergic reaction such as hives, difficulty breathing or a swelling of your face, lips or throat.


What should I do if I miss a dose of Fluorouracil Cream?

If you miss a dose of this medication, take it as soon as you remember. If it is almost time for your next dose, then skip your missed dose.

Can I use sunscreen with Efudex Cream?

You can apply moisturizer or sunscreen to the affected area, two hours after applying this medication.

A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

Your Lowest Price, Guaranteed

Our goal is to bring you the most affordable medication. If you find a lower price advertised by another website or your local pharmacy, we’ll match that price or beat it by 10% of the difference.* Call us at 1-877-204-1507 and a member of our CareTeam will be happy to assist you.

Call 1-877-204-1507
* Some exceptions may apply
Some exceptions may apply. To qualify for price matching, competitors must meet our standards for patient safety. Advertised prices must be for medication of the same type, strength, quantity, and form.

Real Customers, Honest Reviews

Hello, as a retired USA pharmacist, I can say that Canada Pharmacy Depot has 2 awesome points in my book. Number 1 is the saving cost. If I use my Medicare D plan, I'm into the "coverage gap" in January. It amazes me how over priced the USA system is, sad I have to say that, but it is totally true. Point Number 2 is your customer service. I used to try to go out of my way for patients. I'm definitely glad seeing the staff at Canada Pharmacy Depot embodies that same desire....KUDOS... Paul
Paul February 27, 2020

Real Customers, Honest Reviews

I was very satisfied with the service and knowledge of your staff. Very professional and friendly. This was my first order and I felt very comfortable dealing with your pharmacy. I was walked through every step and my questions were answered.
Susan February 21, 2020

Real Customers, Honest Reviews

I was very satisfied with your information about how to set up my account. Thanks!
Neoma February 21, 2020

Real Customers, Honest Reviews

Wonderful service. Appreciate that you try to keep costs as low as you can.
Carolyn February 19, 2020

Real Customers, Honest Reviews

Once the details were done setting up the account, the follow up on keeping me posted on the order was excellent. The prescription came well within the expected delivery date. Will be following up shortly for my refill.
Roslyn February 19, 2020

Real Customers, Honest Reviews

I have not yet received the meds yet, but so far my experience with your reps has been fantastic! Very smart, very friendly and understanding. She was a great representative who explained the details and put my mind at ease.
Barbara February 18, 2020

Real Customers, Honest Reviews

My order arrived today...love you guys. I have a serious illness and because of your ability to get my medicine to me for a price that I can afford...I'm alive and love ALL Canadians!
George February 18, 2020

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Your commitment is awesome.....thank you
Barbara February 11, 2020

Real Customers, Honest Reviews

I have not used the Canada Pharmacy Depot prior to this order. I was pleased that you did a price match and the order was managed quickly and efficiently after providing the necessary prescription. I will use the CPD again! Don
Donald January 30, 2020

Real Customers, Honest Reviews

The Canada Pharmacy Depot exceeded my expectations. They made it easy to send them the Rx and the wait time was not long before my order arrived.
ROBERT October 20, 2019
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