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Canada Pharmacy Depot Prescription Required
IMPORTANT NOTE: A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.
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Buy Efudex Cream (Fluorouracil Cream) Online

Are you looking to buy Fluorouracil Cream and other prescription medications for a fraction of what you usually pay? Buying medications with Canada Pharmacy Depot can save you up to 90% on the cost of Fluorouracil Cream. It’s safe, convenient and quick from our Canadian pharmacy and you can order online or call us 7 days a week.

What is Fluorouracil Cream?

Fluorouracil Cream and the brand name Efudex Cream are medications used to treat pre-cancerous and cancerous skin growths and scaly overgrowths of the skin. Fluorouracil interferes with the growth of skin cells and works by causing the death of cells which grow fastest such as abnormal skin cells.

Always read the patient information and instructions carefully before using this medication. Follow your doctor’s directions.

  • Clean and rinse the affected area and dry with a towel. Wait ten minutes before applying Efudex Cream.
  • Wash your hands before and after using this medication unless it is being used to treat a hand condition.
  • Use finger tips or a non-metal applicator to apply Efudex to the affected area. Use enough medication to cover the entire area with a thin film. Smooth the cream gently onto the affected skin.
  • Fluorouracil cream should not be applied to open wounds or skin which is irritated, infected or peeling.
  • Do not cover the treated skin area unless directed to by a doctor.
  • Wait two hours before applying moisturizer or sunscreen.


Make sure to tell your doctor and pharmacist:

  • If you have any drug or other allergies.
  • Which other prescription and non-prescription medications you currently take.
  • Your medical history especially of dihydropyrimidine dehydrogenase (DPD) enzyme deficiency.

Also be aware that:

  • This medication should not be used during pregnancy. Use effective birth control to prevent pregnancy while using fluorouracil cream. Ask your doctor about how long to prevent pregnancy after ending treatment.
  • You should not breast feed while using fluorouracil cream.
  • Efudex Cream should not be used by anyone under the age of 18.

Side effects of Efudex

Common Fluorouracil Cream side effects may include but are not limited to:

  • Skin irritation, burning, pain, redness, dryness, swelling, tenderness or changes in skin color at the site of application.
  • Trouble sleeping.
  • Eye irritation, stinging or watering.
  • Temporary hair loss.
  • Abnormal taste in the mouth.
  • Irritability.

Contact your doctor if you experience any of the following side effects of Efudex Cream:

  • Stomach or abdominal pain.
  • Bloody diarrhea.
  • Vomiting.
  • Mouth sores.
  • Easier bruising or bleeding.
  • Signs of infection such as fever, chills or a persistent sore throat.
  • Signs of an allergic reaction such as hives, difficulty breathing or a swelling of your face, lips or throat.


What should I do if I miss a dose of Fluorouracil Cream?

If you miss a dose of this medication, take it as soon as you remember. If it is almost time for your next dose, then skip your missed dose.

Can I use sunscreen with Efudex Cream?

You can apply moisturizer or sunscreen to the affected area, two hours after applying this medication.

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JudithNovember 30, 2022

Great job! Very reasonable prices and fast service

KathleenOctober 5, 2022

Good experience.

ElizabethSeptember 30, 2022

Great service and very timely.

ChrisSeptember 30, 2022

Great service from start to finish.

EdwardSeptember 29, 2022

I had wonderful service as I have every time I’ve dealt with you. My questions were answered promptly and I received my medication right on time. Thank you so much.

LindaSeptember 29, 2022

A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

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Our goal is to bring you the most affordable medication. If you find a lower price advertised by another website or your local pharmacy, we’ll match that price or beat it by 10% of the difference.* Call us at 1-877-204-1507 and a member of our CareTeam will be happy to assist you.

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Some exceptions may apply. To qualify for price matching, competitors must meet our standards for patient safety. Advertised prices must be for medication of the same type, strength, quantity, and form.