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What is Fluorouracil Cream?

Fluorouracil Cream and the brand name Efudex Cream are medications used to treat pre-cancerous and cancerous skin growths and scaly overgrowths of the skin. Fluorouracil interferes with the growth of skin cells and works by causing the death of cells which grow fastest such as abnormal skin cells.

Always read the patient information and instructions carefully before using this medication. Follow your doctor’s directions.

• Clean and rinse the affected area and dry with a towel. Wait ten minutes before applying Efudex Cream.
• Wash your hands before and after using this medication unless it is being used to treat a hand condition.
• Use finger tips or a non-metal applicator to apply Efudex to the affected area. Use enough medication to cover the entire area with a thin film. Smooth the cream gently onto the affected skin.
• Fluorouracil cream should not be applied to open wounds or skin which is irritated, infected or peeling.
• Do not cover the treated skin area unless directed to by a doctor.
• Wait two hours before applying moisturizer or sunscreen.

Make sure to tell your doctor and pharmacist:

• If you have any drug or other allergies.
• Which other prescription and non-prescription medications you currently take.
• Your medical history especially of dihydropyrimidine dehydrogenase (DPD) enzyme deficiency.

Also be aware that:

• This medication should not be used during pregnancy. Use effective birth control to prevent pregnancy while using fluorouracil cream. Ask your doctor about how long to prevent pregnancy after ending treatment.
• You should not breast feed while using fluorouracil cream.
• Efudex Cream should not be used by anyone under the age of 18.

Common Fluorouracil Cream side effects may include but are not limited to:

• Skin irritation, burning, pain, redness, dryness, swelling, tenderness or changes in skin color at the site of application.
• Trouble sleeping.
• Eye irritation, stinging or watering.
• Temporary hair loss.
• Abnormal taste in the mouth.
• Irritability.

Contact your doctor if you experience any of the following side effects of Efudex Cream:

• Stomach or abdominal pain.
• Bloody diarrhea.
• Vomiting.
• Mouth sores.
• Easier bruising or bleeding.
• Signs of infection such as fever, chills or a persistent sore throat.
• Signs of an allergic reaction such as hives, difficulty breathing or a swelling of your face, lips or throat.

What should I do if I miss a dose of Fluorouracil Cream?

If you miss a dose of this medication, take it as soon as you remember. If it is almost time for your next dose, then skip your missed dose.

Can I use sunscreen with Efudex Cream?

You can apply moisturizer or sunscreen to the affected area, two hours after applying this medication.