Differin Gel, a retinoid-like compound, treats acne in adults and children 12 years and older. It works by stopping pimples from forming under the surface of the skin.

Differin Gel, exactly as your doctor has prescribed it for you.

• Differin gel is usually applied once daily in the evening.
• Wash your hands before applying for this medicine.
• Clean your skin with a mild, non-medicated skin cleanser before applying Differin Gel. Pat the skin dry with a clean towel.
• Apply a thin layer to the entire face or other affected skin areas. Avoid applying the medicine to the creases of your nose or lips.
• Do not apply to open wounds or on sunburned, windburned, dry, chapped, or irritated skin. 

Before using Differin Gel, tell your doctor if you have the following:

• Allergies
  Any unusual or allergic reaction to this medicine or other medicines,
• Pediatric
  In teenagers, Differin Gel is not expected to cause different side effects or problems than it does in adults.
• Breastfeeding or Pregnancy
• Drug Interactions
  If you are taking other or nonprescription medicine,
• Other Interactions
  Using alcohol or tobacco with certain medicines may also cause interactions to occur.
• Medical History especially:
  Eczema or Seborrheic dermatitis—Differin Gel may cause or increase the irritation associated with eczema or seborrheic dermatitis.

Common side effects of Differin Gel include,

A brief sensation of warmth or stinging may occur right after applying the medication. Skin redness, dryness, itching, scaling, mild burning, or worsening of acne may occur during the first 2-4 weeks of using the medication. These effects usually decrease with continued use. 

Tell your doctor immediately if you have any serious side effects, including very red/irritated skin, an intense burning sensation, eye redness and watering (conjunctivitis), eyelid swelling, and skin discoloration.

These are not a complete list of possible side effects. Contact your doctor or pharmacist if you notice other effects not listed above.

Should you moisturize before or after Differin Gel?

It is best to apply Differin Gel first to give your skin the best chance at absorbing the full dose. Once the medication is completely rubbed in and your skin is dry to the touch, you can apply a moisturizer.

Can you use Differin Gel all over your face?

You can and should apply Differin Gel to your entire face unless your provider tells you otherwise. Differin Gel works best for facial acne when applied to your entire face rather than to individual pimples as a "spot" treatment.

What side effects can Differin Gel cause?

Skin redness, dryness, itching, scaling, mild burning, or worsening of acne may occur during the first 2-4 weeks of using Differin Gel.