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What is Cymbalta?

Cymbalta (duloxetine) is a medication which is prescribed to treat anxiety, depression and to relieve nerve pain. Duloxetine can help to improve your energy levels, mood, appetite and sleep while decreasing nervousness. Cymbalta is a serotonin-norepinephrine reuptake inhibitor (SNRI) which restores the balance of the natural chemicals serotonin and norepinephrine in the brain

Always read the patient information and instructions carefully before using this medication. Follow your doctor’s directions.

• Duloxetine should be taken orally. It can be taken with or without food, although taking this with food may help prevent nausea. This medication is typically taken once or twice a day.
• Swallow Cymbalta whole without crushing, breaking or opening the capsules.
• It may take up to four weeks before your symptoms improve. Continue taking Cymbalta regularly and do not stop taking this medication without speaking to a doctor.

Make sure to tell your doctor and pharmacist:

• If you have any drug or other allergies.
• Which other prescription and non-prescription medications you currently take.
• Your medical history especially of bleeding disorders, blood clotting disorders, kidney disease, liver disease, seizures, epilepsy, difficulty urinating, high blood pressure, glaucoma, diabetes, bipolar disorder, manic depression or suicidal thoughts.
• If you have ever had a drug addiction.
• If you are pregnant, planning on pregnancy or breast feeding. Cymbalta may cause problems in a newborn if taken during the third trimester of pregnancy.

Also be aware that:

• Some young people may have suicidal thoughts when first taking an antidepressant. Your family or other caregivers should be alert to mood changes. Check your progress regularly with a doctor.
• Older adults and children may be more sensitive to the side effects of this medication.

Common Cymbalta side effects may include but are not limited to:

• Dry mouth.
• Drowsiness, tiredness or dizziness.
• Increased sweating.
• Nausea or constipation.
• Weight loss or a loss of appetite.

Contact your doctor if you experience any of the following side effects of duloxetine:

• New or worsening such as mood or behavior changes, anxiety, panic attacks, sleeping problems, impulsiveness, irritation, agitation, hostility, aggressiveness, restlessness, hyperactivity, increase in depression or thoughts about suicide or hurting yourself.
• Lightheadedness or feeling like you might pass out.
• Eye pain, redness or swelling or vision changes.
• Unusual bleeding or easy bruising.
• Seizures.
• Difficult or painful urination.
• Signs of a manic episode such as increased energy, reckless behavior, racing thoughts, extreme happiness, extreme irritation, talking more than usual or severe sleep problems.
• Signs of low levels of sodium such as confusion, headaches, vomiting, slurred speech, severe weakness, loss of coordination or feeling unsteady.
• Signs of liver problems such as itching, dark urine, right-sided upper stomach pain, itching or jaundice.
• Signs of serotonin syndrome such as nausea, vomiting, diarrhea, agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching or a loss of coordination.
• Signs of a severe skin reaction such as fever, sore throat, swelling in your face or tongue, burning in your eyes or a skin pain which is followed by a red or purple skin rash that spreads especially to your face or upper body and causes blistering and peeling.
• Signs of an allergic reaction such as hives, difficulty breathing or a swelling of your face, lips or throat.

What should I do if I miss a dose of Cymbalta?

If you miss a dose of this medication, take it as soon as you remember. If it is almost time for your next dose, then skip your missed dose.

How long does it take Cymbalta to work?

It may take up to four weeks before your symptoms improve. Continue taking Cymbalta regularly and do not stop taking this medication without speaking to a doctor.