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What is Combipatch?

Combipatch is a combination medication containing estradiol and norethindrone acetate and is used to treat symptoms of menopause such as hot flashes and vaginal dryness, burning and itching. Combipatch may also be used before menopause to treat a lack of estrogen caused by hypogonadism, primary ovarian failure and surgical removal of the ovaries.

Always read the patient information and instructions carefully before using this medication. Follow your doctor’s directions.

• Peel off the back of the patch and press it firmly to a clean and dry area of your lower stomach. Hold the patch for around ten seconds to ensure it is placed securely.
• Combipatch patches are normally replaced twice a week. When replacing your patch, apply it to a different area and wait at least a week before applying another patch to the same area.
• If your patch comes off, reapply it to a different area. If it does not completely stick, apply a new patch and wear it for the rest of the scheduled period. You should not wear multiple patches at the same time.
• Combipatch should not be applied to irritated, oily or broken skin.
• Do not expose the patch to the sun for long periods of time.
• Tell your doctor if your condition persists or worsens.

Make sure to tell your doctor and pharmacist:

• If you have any drug or other allergies.
• Which other prescription and non-prescription medications you currently take.
• Your medical history especially of vaginal bleeding of an unknown cause, stroke, heart disease, liver disease, kidney disease, blood clotting disorders, high blood pressure, diabetes, high blood cholesterol, obesity, lupus, underactive thyroid, mineral imbalance, hypoparathyroidism, uterus problems, gallbladder disease, asthma, seizures, migraines, porphyria and mental or mood disorders such as dementia or depression.
• Your personal and family history of breast lumps, cancer, blood clots and angioedema.
• If you will be or have just had surgery or if you will be confined to a bed or chair for an extended period of time, such as on a long flight. These conditions can increase your risk of getting blood clots and you may need to temporarily stop this medication or take special precautions.

Also be aware that:

• You should not smoke or use tobacco while taking this medication. Estrogens combined with smoking further increases the risk of blood clots, heart attack, stroke and high blood pressure, especially in women over 35.
• Combipatch can cause dark or blotchy areas on your skin and face which may be worsened by sunlight. You should limit your time in the sun and wear protective clothing and use sunscreen. Avoid tanning booths and sunlamps.
• If you wear contact lenses or if you are nearsighted, you may develop vision problems. Consult your eye doctor if this occurs.
• If you have an MRI test, inform testing personnel that you use Combipatch as it may need to be removed before the test.
• Older adults may be more sensitive to the side effects of Combipatch.
• Combipatch must not be used during pregnancy.
• This medication passes into breast milk and may reduce the quality and quantity produced. Ask your doctor for more information.

Common Combipatch side effects may include but are not limited to:

• Redness or irritation where the patch is worn.
• Nausea or vomiting.
• Bloating, weight gain or swelling.
• Breast pain or stomach cramps./li>
• Vaginal itching, discharge, spotting or breakthrough bleeding.
• Headaches.
• Thinning scalp hair.

Contact your doctor if you experience any of the following side effects of Combipatch:

• Signs of a heart attack such as chest pain or pressure, nausea, sweating or a pain spreading to your jaw or shoulder.
• Increased blood pressure such as severe headache, blurred vision, anxiety, nosebleed or a pounding in your neck or ears.
• Signs of a blood clot such as sudden vision loss, shortness of breath, stabbing chest pain, coughing up blood or a pain or warmth in one or both legs.
• Signs of a stroke such as sudden severe headache, slurred speech, vision or balance problems or a sudden numbness or weakness especially on one side of the body.
• Breast lumps.
• Swelling or tenderness in the stomach.
• Signs of high levels of calcium in your blood such as nausea, vomiting, muscle weakness, constipation, bone pain, lack of energy or increased thirst or urination,.
• Pelvic pain or unusual vaginal bleeding.
• Confusion, memory problems or unusual behavior.
• Jaundice.
• Signs of an allergic reaction such as hives, difficulty breathing or a swelling of your face, lips or throat.

What should I do if my Combipatch patch falls off?

If your patch comes off, reapply it to a different area. If it does not completely stick, apply a new patch and wear it for the rest of the scheduled period. You should not wear multiple patches at the same time.

What else is Combipatch called?

Combipatch is also known as Estalis Patch. Estalis Patch is not a generic alternative but the same brand name medication with a different name internationally.