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What is Combigan?

Combigan is an eye drop medication containing brimonidine and timolol which is used to treat forms of high pressure inside the eye such as open-angle glaucoma or ocular hypertension. Brimonidine is a alpha agonist which works by allowing better fluid drainage reducing the amount of fluid inside the eye while timolol is a beta-blocker which reduces pressure inside the eye.

Always read the patient information and instructions carefully before using this medication. Follow your doctor’s directions.

• Combigan is usually applied twice daily, twelve hours apart.
• Wash your hands before using Combigan. Do not touch the dropper tip or let it touch any other surface to avoid contamination leading to an eye infection.
• Tip your head back and use your finger to pull down your lower eyelid to create a small pocket. Holding the dropper above the eye, look away from the dropper and squeeze out a drop into the pocket. Use your finger to apply gentle pressure to the corner of your eye to prevent the fluid draining away from your eye ducts.
• If you use more than one drop of Combigan, you should wait around five minutes between drops and at least ten minutes before applying any other eye drops.
• If you wear contact lenses, remove them before using Combigan and wait at least fifteen minutes before putting your lenses back in.
• Do not use Combigan eye drops if the liquid has particles in it or if it has changed color.
• Tell your doctor if you have any eye infections or injuries.

Make sure to tell your doctor and pharmacist:

• If you have any drug or other allergies.
• Which other prescription and non-prescription medications you currently take.
• Your medical history especially of congestive or severe heart failure, heart disease, AV block, coronary artery disease, lung disease, kidney disease, liver disease, stroke, blood clot, circulation problems, asthma, high or low blood pressure, depression, thyroid disorder, diabetes, myasthenia gravis or glaucoma.
• If you develop an eye injury, infection of if you have eye surgery. Your doctor may advise you to start using a new bottle of Combigan.
• If you are pregnant, planning pregnancy or breast feeding.

Also be aware that:

• This medication may make you dizzy, drowsy or blur your vision. Do not drive, operate machinery or do anything else requiring alertness or clear vision until it can be done safely.
• If you have diabetes, Combigan can prevent the fast or pounding heartbeat that you would normally feel when your blood sugar levels falls too low.

Common Combigan side effects may include but are not limited to:

• Temporary blurred vision.
• Temporary stinging, itching, redness or burning of the eye.
• Dry or watery eyes.
• Dry mouth.
• Feeling as if something is in your eye.
• Dizziness or drowsiness.
• Headache.

Contact your doctor if you experience any of the following side effects of Combigan:

• Eye pain, discharge or swelling.
• Vision changes or sensitivity to light.
• Slow or irregular heartbeat.
• Unusual tiredness or muscle weakness.
• Mental or mood changes.
• Numbness, pain or coldness in the hands or feet.
• Shortness of breath.
• Swelling of the ankles or feet.
• Sudden or unexplained weight gain.
• Signs of an allergic reaction such as hives, difficulty breathing or a swelling of your face, lips or throat.

What should I do if I miss a dose of Combigan?

If you miss a dose of this medication, take it as soon as you remember. If it is almost time for your next dose, then skip your missed dose. Do not take extra medication to make up for a missed dose.

What is the Combigan generic alternative?

Generic Combigan is known as brimonidine/timolol and is available in 0.25/0.5% strength.