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What is Leflunomide?

Leflunomide and the brand name Arava are medications used to treat rheumatoid arthritis which is a condition where your body’s immune system attacks healthy tissue around the joints because it fails to recognize the body as itself. Leflunomide works by weakening your immune system in order to reduce swelling and inflammation.

Always read the patient information and instructions carefully before using this medication. Follow your doctor’s directions.

• Arava is taken orally and can be taken with or without food. It is typically taken once a day.
• Your blood, blood pressure and liver function may need to be regularly checked while taking leflunomide.
• After you stop taking leflunomide, you may need further treatment to eliminate leflunomide from your body, otherwise it could remain for up to two years.

Make sure to tell your doctor and pharmacist:

• If you have any drug or other allergies.
• Which other prescription and non-prescription medications you currently take especially if you take any medications which weaken your immune system.
• Your medical history especially of liver disease, hepatitis, severe or uncontrolled infections, kidney disease, nerve problems, neuropathy, diabetes, tuberculosis, a weak immune system or bone marrow disorder.

Also be aware that:

• Leflunomide should not be used if you are pregnant. You will need to have a negative pregnancy test before starting this medication. Use birth control while taking this mediation and until you have completed a ‘drug elimination’ procedure.
• Your liver function may need to be tested frequently while taking this medication.
• Do not breast feed while taking Arava.

Common leflunomide side effects may include but are not limited to:

• Diarrhea or nausea.
• Dizziness.

Contact your doctor if you experience any of the following side effects of Arava:

• Any rash.
• Raised blood pressure.
• Coughing.
• Mental or mood changes.
• Hair loss.
• Increased thirst or urination.
• Muscle pain or cramp.
• Vision changes.
• Unexplained weight loss.
• Unusual tiredness.
• Numbness or tingling of your hands or feet.
• Fast or pounding heartbeat.
• Unusual growths or lumps.
• Chest pain.
• Easy bruising or bleeding.
• Signs of an infection such as fever, swollen lymph nodes, chills or a persistent sore throat.
• Signs of an allergic reaction such as hives, difficulty breathing or a swelling of your face, lips or throat.

What should I do if I miss a dose of leflunomide?

If you miss a dose of this medication, take it as soon as you remember. If it is almost time for your next dose, then skip your missed dose.

How long does leflunomide stay in the body?

After you stop taking leflunomide, you may need further treatment to eliminate leflunomide from your body, otherwise it could remain for up to two years.