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What is Anafranil?

Anafranil and the generic alternative clomipramine are antidepressants used to treat obsessive compulsive disorder (OCD) by restoring the balance of natural chemicals such as serotonin in the brain. This can help to decrease unwanted or persistent thoughts and helps to reduce the urge to perform repeated tasks that can interfere with your daily living.

Always read the patient information and instructions carefully before using this medication. Follow your doctor’s directions.

• You should take clomipramine with food to reduce the chance of stomach upset.
• It may take four weeks before your symptoms improve. Continue taking your medication and speak to a doctor if your symptoms do not improve after this time.
• Do not stop taking Anafranil suddenly. Ask your doctor about how to stop taking this medication.

Make sure to tell your doctor and pharmacist:

• If you have any drug or other allergies.
• Which other prescription and non-prescription medications you currently take, especially any other anti-depressants you have taken within the last five weeks.
• Your medical history especially of liver disease, bipolar disorder, manic depression, schizophrenia or other mental illness, seizures, head injuries, heart disease, low blood pressure, glaucoma, overactive thyroid, adrenal gland tumors or urination problems,
• Any history of alcoholism.
• If you are pregnant or planning on pregnancy.

Also be aware that:

• You should not use Anafranil if you have used an MAO inhibitor within the past 14 days. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
• Some young people may have suicidal thoughts when first taking anti-depressants. Your doctor may want to check your progress regularly. Your family or other caregivers should be alert to mood changes or changes in your symptoms.
• Do not breast feed while using this medication.
• Clomipramine shouldn’t be used by anyone younger than 18.

Common clomipramine side effects may include but are not limited to:

• Trouble concentrating, anxiety, restlessness or memory problems.
• Dry mouth or loss of appetite.
• Nausea, upset stomach or constipation.
• Loss of appetite or changes to your weight.
• Dizziness, drowsiness or tiredness.
• Decreased sex drive, impotence or difficulty in having an orgasm.
• Changes to your weight or appetite.
• Increased sweating, numbness or tingling.
• Changes to your vision.

Contact your doctor if you experience any of the following side effects of Anafranil:

• New or worsening such as mood or behavior changes, anxiety, panic attacks, sleeping problems, impulsiveness, irritation, agitation, hostility, aggressiveness, restlessness, hyperactivity, increase in depression or thoughts about suicide or hurting yourself.
• Thoughts of hurting yourself, confusion or extreme fear.
• Difficult or painful urination.
• Eye pain, swelling or vision problems such as blurred vision, tunnel vision or seeing halos around lights.
• Rapid heart rate, tremors, shaking or seizures.
• Symptoms of serotonin syndrome such as: agitation, hallucinations, a loss of coordination, fever, sweating, shivering, a fast heart rate, muscle stiffness, twitching, vomiting, nausea or diarrhea.
• Symptoms of a serious drug reaction such as skin rash, fever, swollen glands, flu symptoms, muscle aches, severe weakness, unusual bruising, or jaundice. This reaction can occur several weeks after starting to use clomipramine.
• Signs of an allergic reaction such as hives, difficulty breathing or a swelling of your face, lips or throat.

What should I do if I miss a dose of Anafranil?

If you miss a dose of this medication, take it as soon as you remember. If it is almost time for your next dose, then skip your missed dose.

How long does it take clomipramine to work?

It may take four weeks before your symptoms improve. Continue taking your medication and speak to a doctor if your symptoms do not improve after this time.