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What is Activella?

Activella is a combination medication combining estradiol and norethindrone and is prescribed to help treat symptoms of menopause such as vaginal dryness and hot flashes which are caused by your body making less estrogen. Estradiol is a form of estrogen and norethindrone is a progestin which helps to reduce the risk of cancer of the uterus which may be caused by taking estrogen.

Always read the patient information and instructions carefully before using this medication. Follow your doctor’s directions.

• Take Activella orally with or without food. Taking Activella with food or after a meal may help to prevent stomach upset.
• This medication is typically taken once a day.
• Your doctor may want to check your progress regularly to determine whether you should continue with this treatment.
• Self-examine your breasts for lumps each month and have an annual mammogram while taking this medication.
• Tell your doctor if your condition does not improve.

Make sure to tell your doctor and pharmacist:

• If you have any drug or other allergies.
• Which other prescription and non-prescription medications you currently take.
• Your medical history especially of undiagnosed vaginal bleeding, liver disease, bleeding disorders, heart attack, stroke, blood clots, cancer, high blood pressure, diabetes, high cholesterol, heart disease, liver problems, jaundice, epilepsy or other seizure disorders, kidney disease, gallbladder disease, asthma, migraines, lupus, porphyria, endometriosis, uterine fibroid tumors, thyroid disorders or high levels of calcium in your blood.
• Your personal family history of angioedema.
• If you will be having surgery.
• If you are overweight or if you smoke.
• If you are breast feeding.

Also be aware that:

• Activella should not be used if you are pregnant.
• Using Activella may increase your risk of cancer of the breast, uterus or ovaries.

Common Activella side effects may include but are not limited to:

• Nausea, vomiting or stomach upset.
• Bloating or weight changes.
• Headaches.
• Breast tenderness.

Contact your doctor if you experience any of the following side effects of Activella:

• Mental or mood changes such as depression or memory loss.
• New or increased vaginal discharge, odor, irritation or itching.
• Severe stomach or abdominal pain.
• Unusual vaginal bleeding such as spotting, breakthrough bleeding prolonged or recurrent bleeding.
• Breast lumps.
• Dark urine.
• Persistent nausea or vomiting.
• Jaundice.
• Increased thirst or urination.
• Swelling of your hands or feet.
• Signs of a problem caused by blood clots such as weakness on one side of the body, slurred speech, chest pain, jaw pain, pain in your left arm, vision changes including partial or complete blindness, confusion, sudden dizziness, fainting, coughing up blood, unusual sweating, trouble breathing or a pain, tingling, numbness, swelling, weakness or redness in your arms or legs.
• Signs of an allergic reaction such as hives, difficulty breathing or a swelling of your face, lips or throat.

 What should I do if I miss a dose of Activella?

If you miss a dose of this medication, take it as soon as you remember. If it is almost time for your next dose, then skip your missed dose.

What else is Activella called?

Activella is also known as Activelle and Activelle LD. Activelle and Activelle LD are not a generic alternatives but the same brand name medication with different names internationally.