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IMPORTANT NOTE: A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.
Difference between Brand & Generic?

Buy Activella Online

It has never been easier to buy your prescription medications online from Canadian pharmacies. Canada Pharmacy Depot lets you buy Activella quickly and for a fraction of the cost you are used to paying in the US. Order online today or call us 7 days a week.

What is Activella?

Activella is a combination medication combining estradiol and norethindrone and is prescribed to help treat symptoms of menopause such as vaginal dryness and hot flashes which are caused by your body making less estrogen. Estradiol is a form of estrogen and norethindrone is a progestin which helps to reduce the risk of cancer of the uterus which may be caused by taking estrogen.

Always read the patient information and instructions carefully before using this medication. Follow your doctor’s directions.

  • Take Activella orally with or without food. Taking Activella with food or after a meal may help to prevent stomach upset.
  • This medication is typically taken once a day.
  • Your doctor may want to check your progress regularly to determine whether you should continue with this treatment.
  • Self-examine your breasts for lumps each month and have an annual mammogram while taking this medication.
  • Tell your doctor if your condition does not improve.


Make sure to tell your doctor and pharmacist:

  • If you have any drug or other allergies.
  • Which other prescription and non-prescription medications you currently take.
  • Your medical history especially of undiagnosed vaginal bleeding, liver disease, bleeding disorders, heart attack, stroke, blood clots, cancer, high blood pressure, diabetes, high cholesterol, heart disease, liver problems, jaundice, epilepsy or other seizure disorders, kidney disease, gallbladder disease, asthma, migraines, lupus, porphyria, endometriosis, uterine fibroid tumors, thyroid disorders or high levels of calcium in your blood.
  • Your personal family history of angioedema.
  • If you will be having surgery.
  • If you are overweight or if you smoke.
  • If you are breast feeding.

Also be aware that:

  • Activella should not be used if you are pregnant.
  • Using Activella may increase your risk of cancer of the breast, uterus or ovaries.

Side Effects of Activella

Common Activella side effects may include but are not limited to:

  • Nausea, vomiting or stomach upset.
  • Bloating or weight changes.
  • Headaches.
  • Breast tenderness.

Contact your doctor if you experience any of the following side effects of Activella:

  • Mental or mood changes such as depression or memory loss.
  • New or increased vaginal discharge, odor, irritation or itching.
  • Severe stomach or abdominal pain.
  • Unusual vaginal bleeding such as spotting, breakthrough bleeding prolonged or recurrent bleeding.
  • Breast lumps.
  • Dark urine.
  • Persistent nausea or vomiting.
  • Jaundice.
  • Increased thirst or urination.
  • Swelling of your hands or feet.
  • Signs of a problem caused by blood clots such as weakness on one side of the body, slurred speech, chest pain, jaw pain, pain in your left arm, vision changes including partial or complete blindness, confusion, sudden dizziness, fainting, coughing up blood, unusual sweating, trouble breathing or a pain, tingling, numbness, swelling, weakness or redness in your arms or legs.
  • Signs of an allergic reaction such as hives, difficulty breathing or a swelling of your face, lips or throat.


 What should I do if I miss a dose of Activella?

If you miss a dose of this medication, take it as soon as you remember. If it is almost time for your next dose, then skip your missed dose.

What else is Activella called?

Activella is also known as Activelle and Activelle LD. Activelle and Activelle LD are not a generic alternatives but the same brand name medication with different names internationally.

A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

Your Lowest Price, Guaranteed

Our goal is to bring you the most affordable medication. If you find a lower price advertised by another website or your local pharmacy, we’ll match that price or beat it by 10% of the difference.* Call us at 1-877-204-1507 and a member of our CareTeam will be happy to assist you.

Call 1-877-204-1507
* Some exceptions may apply
Some exceptions may apply. To qualify for price matching, competitors must meet our standards for patient safety. Advertised prices must be for medication of the same type, strength, quantity, and form.

Real Customers, Honest Reviews

Great service, pricing and responsive
Lynne August 31, 2021

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Excellent 1st time service!
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Patrick August 30, 2021

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Great customer service and good value compared to drug cost here in the US
Patti Ann August 1, 2021

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Canada Pharmacy Depot is truly one of the best and last places where I can experience truly customer-focused SERVICE! Your staff are always very professional, friendly, knowledgeable, and reliable. I am now old enough to remember when this sort of service was common in the United States. No longer. Thank you for not only providing excellent access to expensive prescriptions, but also a reminder that professionals DO still exist.
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First time customer, a little hesitant. It worked out great. Big savings on script.
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christiane August 30, 2021

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The customer service was really good, but I was very disappointed with how long it took to receive my medicine. Generally, when someone needs medicine, it is important that they get it pretty quick.
Faigy July 15, 2021
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