What Are the Alternatives to Xarelto?

Thursday 28 February 2019
6 minute(s) read

Medically reviewed by

Stefan Reiner, PharmD, RPh
on 1 September 2020

Table of Contents

I. Why Use a Xarelto Alternative

II. Blood Thinners

a. Antiplatelets

b. Xarelto, a Novel Oral Anticoagulant

III. Xarelto vs. Warfarin

IV. Xarelto, Aspirin, and Combination Therapy

V. Xarelto vs. Eliquis and Other Anticoagulants

VI. An Antidote for Anticoagulant Side Effects

VII. Lifestyle Changes and Other Preventive Methods

VIII. Finding Xarelto Online at Canada Pharmacy Depot

Xarelto is a popular anticoagulant, but it’s not the only one out there. If you would rather take Xarelto but for whatever reason cannot, you have other options. There are several alternatives to Xarelto including, Warfarin, Eliquis, and Pradaxa. If you are at risk of developing blood clots, you can save money on your prescriptions through a licensed Canadian pharmacy like Canada Pharmacy Depot. Talk to your doctor will determine if Xarelto is right for you.

Why Use a Xarelto Alternative

There are many legitimate reasons why a patient may want to switch from Xarelto to a different but similar drug. Reasons for switching include:

  • Allergies — This can include an allergy to Xarelto or towards an ingredient in Xarelto.
  • Price 
  • Another anticoagulant — Others may be more effective for some people’s bodies.

So if you’re shopping around for a new anticoagulant, you’ve come to the right place! Remember, this article is meant to be taken as general information only, not medical advice. Use it as a jumping-off point for having a conversation with your doctor. Never change up your prescription drugs without first consulting a health-care professional.

An up-close shot shows a hand in a purple glove holding up two test tubes of blood with purple caps against a blurred background of similar tubes.

Blood Thinners

First, let’s review what anticoagulants are.

Also known as blood thinners, anticoagulants help prevent the formation of blood clots. Blood clots in your veins and arteries can block blood flow and cause a pulmonary embolism (PE), among other possible complications. [1]


Antiplatelets are also known as blood thinners but are in a different family than anticoagulants. Antiplatelets include drugs like aspirin that prevent platelets (a certain type of blood cell) from clotting. Meanwhile, anticoagulants work by slowing the body’s clotting process down.


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Xarelto, a Novel Oral Anticoagulant

Xarelto (generic name: rivaroxaban) may be prescribed to a patient who has recently undergone surgery for a procedure like a hip or knee replacement. Generic Xarelto was previously unavailable, but you can now purchase it at discounted prices through Canada Pharmacy Depot. [2] It is sometimes grouped together with other medications of the novel oral anticoagulant (NOAC) group like Eliquis (apixaban) and Pradaxa (dabigatran). [3]

Unlike Warfarin, Xarelto requires blood testing and dietary restrictions, but it has fewer drug interactions.

Xarelto vs. Warfarin

Before Xarelto, there was warfarin. Warfarin (also known by its brand name Coumadin) is an older anticoagulant that is still used today. While warfarin can be used by people with artificial heart valves, Xarelto’s manufacturer specifically states that Xarelto should not be used in patients with artificial heart valves. So warfarin wins, right?

Not so fast. Warfarin treatment requires you to be vigilant about your diet as well as other drugs you take. Warfarin treatment also requires regular blood testing, which may be inconvenient for many patients. [4]

Xarelto, Aspirin, and Combination Therapy

Because aspirin also fights clotting, some patients may wonder whether they can switch from Xarelto treatment to aspirin treatment. [5] Aspirin may be more affordable because it is widely available as a generic and can be bought over-the-counter.

A recent study found that aspirin may be a good way to prevent deep vein thrombosis (DVT) after a lower limb surgery. [6] The study also noted aspirin has a safer side effect profile and is more cost-effective.

But never buy aspirin yourself with the intention of starting daily aspirin therapy without first consulting with your doctor. It’s not the same thing as taking a daily multivitamin.

Your doctor will carefully weigh the benefits and risks of using aspirin. One well-known risk of aspirin is an increased risk of bleeding. This bleeding isn’t restricted to getting a cut; some risks include internal gastrointestinal bleeding, which may not be immediately noticeable. [7]

A person is taking a pill out of her pill organizer.

Xarelto vs. Eliquis and Other Anticoagulants

There are several options for anticoagulants, like Eliquis and Pradaxa, but what's the difference between these drugs and Xarelto? There are many complex ways in which these drugs are similar and/or different. In choosing the right drug for you, your doctor will take stock of your full medical history, including any existing medical conditions, age, sex, and other factors. 

So be sure to tell your doctor as much as you can about yourself. This will aid in their prescribing process. Here are just some unique recommendations about NOACs given by the UK National Health Service:

  • Out of apixaban, dabigatran, edoxaban, and rivaroxaban, rivaroxaban was the only drug listed to be indicated for acute management of acute coronary syndrome.
  • When treating a patient who has previously experienced a stroke, doctors are suggested to consider what best reduces secondary stroke and are invited to consider rivaroxaban or apixaban.
  • Patients with a high risk of ischemic stroke but a low risk of bleeding may be most suited for dabigatran. [8]

Again, make sure you have a thorough discussion with your doctor. Be sure to notify them of other drugs you use too, including both prescription and over-the-counter drugs, recreational drugs, and supplements (vitamins and herbs).

An Antidote for Anticoagulant Side Effects

The most well-known adverse side effect of Xarelto and other anticoagulants is uncontrollable bleeding. Warfarin carries this risk too, but vitamin K has long been used as an effective antidote to warfarin’s adverse effects. Pradaxa (dabigatran), a similar drug to Xarelto, also has an established antidote called Praxbind (idacrucizumab).

Recently, the FDA approved a Xarelto antidote called AndexXa (andexanet alfa) in 2018. It works for Eliquis, Xarelto, and Savaysa (edoxaban).[9]

A salt shaker is lying on its side on a place mat and table after having spilled a pile of salt.

Lifestyle Changes and Other Preventive Methods

While simple lifestyle changes can’t always take the place of medicine, certain habits can supplement your goal of reducing clot risk. For example, one doctor recommends staying active for at least 30 minutes a day, six days a week. [10] Avoid being immobile, as that is when your risk of developing clots rises.

Preventing dangerous blood clots also begins with education. Familiarize yourself with the characteristics that raise a person’s risk:

  • Recent surgical procedure
  • Older age (65 years and older)
  • Inactivity, such as prolonged bed rest or travel
  • Obesity
  • Family history
  • …and other risks [11]

You can also discuss the following solutions with your healthcare provider:

  • Wearing compression stockings and loose-fitting clothes
  • Avoiding crossing your legs and changing your position regularly if you will be still for a prolonged time
  • Raising the end of your bed by about four to six inches
  • Eating less salt

Finding Xarelto Online at Canada Pharmacy Depot

Have more questions about Xarelto? At Canada Pharmacy Depot, you can contact us to speak to a licensed pharmacist. Or place your order today and save on Xarelto, other blood thinners, or other medications you need to stay well. We offer shipments straight to your door, saving you time and money.

DISCLAIMER: The content in this article is intended for informational purposes only. This website does not provide medical advice. In all circumstances, you should always seek the advice of your physician and/or other qualified health professionals(s) for drug, medical condition, or treatment advice. The content provided on this website is not a substitute for professional medical advice, diagnosis or treatment.


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